About this Research Topic
Infectious diseases remain a leading cause of morbidity and mortality worldwide. Despite advancements in prevention and treatment, the limited efficacy of some vaccines coupled with the rapid rise in antibiotic resistance underscores an urgent need for innovative preventive and therapeutic approaches. Bacteria have developed sophisticated mechanisms to sense and respond to external stimuli, allowing them to thrive in diverse environments by evading and suppressing host immune responses.
Our growing understanding of bacterial strategies to evade and manipulate host immunity reveals that we are only beginning to uncover the full complexity of these mechanisms. There remain many undiscovered pathways and interactions that hold significant potential for new medical interventions.
A deeper comprehension of how pathogens detect, respond to, and manipulate host immune responses to colonize, persist, and transmit to new hosts will pave the way for promising new leads in vaccine and therapeutic development. This Research Topic aims to present and explore the latest discoveries in bacterial immunosuppressive mechanisms, shedding light on direct bacterial interactions as well as the involvement of microbiota, co-infections, and predisposed conditions. Enhancing our understanding of bacterial pathogenicity will facilitate the development of innovative treatment strategies against infections.
The scope of this collection includes but is not limited to integrating knowledge from both in vitro and in vivo studies on how bacterial toxins suppress host immune responses, cross-kingdom communication, and the role of microbiota in determining infection outcomes. These insights collectively provide novel avenues for therapeutic development.
We welcome contributions in the form of Original Research, Review, and Mini-Review articles focusing on various bacterial species in the following areas:
• Bacterial immunomodulation
• Microbial biofilms and immune evasion
• Quorum sensing and quorum silencing mechanisms
• Bacterial toxins
• Host immune response to infection
• New immunotherapies
• New vaccination strategies
We encourage submissions that provide a deeper understanding of bacterial immunosuppressive strategies and their potential applications in developing effective treatments and preventive measures against infectious diseases.
Our growing understanding of bacterial strategies to evade and manipulate host immunity reveals that we are only beginning to uncover the full complexity of these mechanisms. There remain many undiscovered pathways and interactions that hold significant potential for new medical interventions.
A deeper comprehension of how pathogens detect, respond to, and manipulate host immune responses to colonize, persist, and transmit to new hosts will pave the way for promising new leads in vaccine and therapeutic development. This Research Topic aims to present and explore the latest discoveries in bacterial immunosuppressive mechanisms, shedding light on direct bacterial interactions as well as the involvement of microbiota, co-infections, and predisposed conditions. Enhancing our understanding of bacterial pathogenicity will facilitate the development of innovative treatment strategies against infections.
The scope of this collection includes but is not limited to integrating knowledge from both in vitro and in vivo studies on how bacterial toxins suppress host immune responses, cross-kingdom communication, and the role of microbiota in determining infection outcomes. These insights collectively provide novel avenues for therapeutic development.
We welcome contributions in the form of Original Research, Review, and Mini-Review articles focusing on various bacterial species in the following areas:
• Bacterial immunomodulation
• Microbial biofilms and immune evasion
• Quorum sensing and quorum silencing mechanisms
• Bacterial toxins
• Host immune response to infection
• New immunotherapies
• New vaccination strategies
We encourage submissions that provide a deeper understanding of bacterial immunosuppressive strategies and their potential applications in developing effective treatments and preventive measures against infectious diseases.
Keywords: Quorum sensing, Bacterial toxins, Virulence factors, Bacterial signaling, Immunosuppression, Immunomodulation, Host immunity, Host-pathogen communication, Biofilms, Vaccines, Virulence modulators
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
