About this Research Topic
The high incidence and mortality of pancreatic cancer pose an enormous threat to human health. Despite tremendous progress in the clinical management of malignancies, few have been achieved in pancreatic cancer therapy. In recent years, the appearance of advanced technology and methodology largely propels our understanding of cancer molecular features and the identification of novel therapeutic targets. Accumulating evidence shows dysfunction of the immune system plays a critical role in pancreatic cancer progression. Therefore, an in-depth understanding of immunological characteristics for identifying new immunotherapeutic targets in pancreatic cancer is warranted for enhancing its therapeutic landscape.
The goal of this Research Topic is to provide a forum to advance research on the contribution of technical and methodological improvement to our understanding of the immunological characteristics and regulatory mechanisms in pancreatic cancer as well as to explore potential intervention targets and strategies to improve the prognoses of patients with pancreatic cancer.
This Research Topic welcomes Research (Original Research and Brief Research Report), Review (Review, Mini Review), Perspective, Clinical Trial, and Case Report in the relevant fields, with a particular focus on, but not limited to:
1. Immune subtype of pancreatic cancer
2. Immunotherapeutic molecular biomarker in pancreatic cancer
3. Novel immune checkpoint in pancreatic cancer
4. Immune modulator beyond immune checkpoint in pancreatic cancer
5. Therapeutic target with multiple anti-pancreatic cancer effect
6. Tumoral immunological characteristics in pancreatic cancer
7. Peripheral immunological characteristics in pancreatic cancer
8. Multiomic analyses in pancreatic cancer
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
The goal of this Research Topic is to provide a forum to advance research on the contribution of technical and methodological improvement to our understanding of the immunological characteristics and regulatory mechanisms in pancreatic cancer as well as to explore potential intervention targets and strategies to improve the prognoses of patients with pancreatic cancer.
This Research Topic welcomes Research (Original Research and Brief Research Report), Review (Review, Mini Review), Perspective, Clinical Trial, and Case Report in the relevant fields, with a particular focus on, but not limited to:
1. Immune subtype of pancreatic cancer
2. Immunotherapeutic molecular biomarker in pancreatic cancer
3. Novel immune checkpoint in pancreatic cancer
4. Immune modulator beyond immune checkpoint in pancreatic cancer
5. Therapeutic target with multiple anti-pancreatic cancer effect
6. Tumoral immunological characteristics in pancreatic cancer
7. Peripheral immunological characteristics in pancreatic cancer
8. Multiomic analyses in pancreatic cancer
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Keywords: pancreatic cancer, immune checkpoint, immune modulator, immunological characteristic, immunotherapeutic biomarker, immune subtype
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
