About this Research Topic
Obesity is a multifactorial metabolic disease that is characterized by unbalanced caloric ingestion and energy expenditure majorly associated with increased access to high-caloric and processed food and a modern and sedentary lifestyle. Long-term obesity has been associated with several other co-morbidities such as type 2 diabetes mellitus (T2D), dyslipidemia, cardiovascular diseases, and certain types of cancer. Obesity is frequently related to hormonal dysfunction associated with impaired glucose homeostasis and insulin resistance, two of the major characters involved in T2D onset and progression. Both obesity and T2D are associated with reduced quality of life and life expectancy and cost millions of dollars yearly to health systems worldwide.
Nutritional interventions, such as reduced caloric diets, physical exercise, and pharmacological approaches are known as first-choice strategies in the treatment of obesity and T2D. Either diet and exercise usually improve both conditions, however, due to lack of compliance, might have a low impact on the treatment of obesity and T2D in populations worldwide. In addition, pharmacological and surgical interventions have not only been associated with undesirable side effects and, in some cases reduced efficacy after long-term treatments but may also represent unaffordable costs for populations from poor or developing countries.
Since novel, and alternative low-cost nutritional interventions are highly desirable in the fight against obesity and T2D, this issue aims to highlight novel and emerging low-cost functional food and/or bioactive nutritional interventions for the treatment of obesity and T2D. This research topic aims at strategies that focus on investigating the proposed mechanism of action, and safety profile of some of the novel dietary supplements or bioactive molecules extracted from functional food on glucose homeostasis, inflammation, insulin resistance, hormonal disbalance, altered microbiome, and other obesity and T2D-related dysfunctions in animal models and humans.
Hence, Original Research and Review articles are welcome including but not limited to the following themes: relevance of functional food and/or food-extracted bioactive molecules on the regulation of nutrient intake and energy homeostasis; mechanisms by which bioactive molecules preserve glucose and energy homeostasis in obesity and T2D; nanotechnology-based strategies focusing on better delivery, release, and action of bioactive molecules with the purpose of improving glucose and energy homeostasis in obesity and T2D; and dietetical strategies focusing on the modulation of specific nutrients.
Nutritional interventions, such as reduced caloric diets, physical exercise, and pharmacological approaches are known as first-choice strategies in the treatment of obesity and T2D. Either diet and exercise usually improve both conditions, however, due to lack of compliance, might have a low impact on the treatment of obesity and T2D in populations worldwide. In addition, pharmacological and surgical interventions have not only been associated with undesirable side effects and, in some cases reduced efficacy after long-term treatments but may also represent unaffordable costs for populations from poor or developing countries.
Since novel, and alternative low-cost nutritional interventions are highly desirable in the fight against obesity and T2D, this issue aims to highlight novel and emerging low-cost functional food and/or bioactive nutritional interventions for the treatment of obesity and T2D. This research topic aims at strategies that focus on investigating the proposed mechanism of action, and safety profile of some of the novel dietary supplements or bioactive molecules extracted from functional food on glucose homeostasis, inflammation, insulin resistance, hormonal disbalance, altered microbiome, and other obesity and T2D-related dysfunctions in animal models and humans.
Hence, Original Research and Review articles are welcome including but not limited to the following themes: relevance of functional food and/or food-extracted bioactive molecules on the regulation of nutrient intake and energy homeostasis; mechanisms by which bioactive molecules preserve glucose and energy homeostasis in obesity and T2D; nanotechnology-based strategies focusing on better delivery, release, and action of bioactive molecules with the purpose of improving glucose and energy homeostasis in obesity and T2D; and dietetical strategies focusing on the modulation of specific nutrients.
Keywords: Obesity, Type 2 Diabetes, Functional food, Bioactive compounds, Bioactive molecules, Food nanotechnology, glucose homeostasis, and insulin resistance.
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