About this Research Topic
The disruption of the niche microenvironment may either delay or promote tumor growth. The central nervous system microenvironment is composed of cells including different types of neurons, glia, immune and endothelial cells, and non-cellular components such as the extracellular matrix, soluble factors, and normoxic and hypoxic regions among others. The balance of all the elements of the microenvironment changes drastically depending on the stage of tumor growth and evolution. Soluble factors that are aberrantly secreted from tumor cells towards the microenvironment may increase tumor accommodation allowing cell growth and invasion. Finally, at advanced stages of tumor development, tumor cells recreate a particular niche to foster its survival and energy supply.
The aim of this Research Topic is to generate a discussion regarding the most recent advances in the interaction of the niche in neurological tumors. Understanding the early processes that enable a cancer cell to adapt and survive in distant tissues from the primary tumor, as well as their communication between various niches and how the cells gained the ability to sustain themselves at various tumor development stages, is critical. All these key aspects of cancer cells are important to shed light on new biomarkers and improve early detection, therapy prediction, and survival prognosis. Further research regarding the relationship between neurological tumor cells and one of their niches will also be considered for publication.
We would like to address how the tumor niche contributes to the initiation, progression, and potential aspects to target the niche for cancer therapy. We welcome studies based on neurological tumors involving both pediatric and adult malignancies, in vitro studies containing at least primary cultures or biopsies, ex vivo, in vivo studies in animal models and/or clinical and pre-clinical studies.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases provided without further validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of “Tumor accommodation: the importance of the niche in neurological tumors” Research Topic.
The aim of this Research Topic is to generate a discussion regarding the most recent advances in the interaction of the niche in neurological tumors. Understanding the early processes that enable a cancer cell to adapt and survive in distant tissues from the primary tumor, as well as their communication between various niches and how the cells gained the ability to sustain themselves at various tumor development stages, is critical. All these key aspects of cancer cells are important to shed light on new biomarkers and improve early detection, therapy prediction, and survival prognosis. Further research regarding the relationship between neurological tumor cells and one of their niches will also be considered for publication.
We would like to address how the tumor niche contributes to the initiation, progression, and potential aspects to target the niche for cancer therapy. We welcome studies based on neurological tumors involving both pediatric and adult malignancies, in vitro studies containing at least primary cultures or biopsies, ex vivo, in vivo studies in animal models and/or clinical and pre-clinical studies.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases provided without further validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of “Tumor accommodation: the importance of the niche in neurological tumors” Research Topic.
Keywords: extracellular matrix, immune cells, brain parenchyma, tissue homeostasis, brain cancer, brain vasculature, soluble factors
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
