About this Research Topic
In the past decades, cellular metabolism has emerged to be a pivotal determinant of immune cell functions. In inflammatory disorders, such as sepsis, inflammatory bowel disease (IBD), cardiometabolic inflammation, pneumonia, or hepatitis, the dysregulated immune metabolism contributes to the initiation, progression, and recovery of diseases. Therefore, the rectification of the abnormal metabolism in immune cells is a promising anti-inflammation strategy.
Macrophages are a type of innate immune cells with a wide range of tissue distribution, which have profound impacts on a variety of diseases. Due to their extreme functional plasticity, macrophages quickly respond to microenvironmental cues and participate in almost all aspects of inflammation. They are the major sources of pro-inflammatory as well as anti-inflammatory cytokines and serve as crucial bridges between innate and adaptive immunity. In inflamed tissues, the levels of many metabolites undergo dramatic changes, which substantially affect the functions of macrophages. In addition, the altered uptake or utilization of metabolic substrates (e.g. sugars, amino acids, fatty acids, or their metabolic intermediates) by macrophages determines their pro- or anti-inflammatory properties. Besides the endogenous metabolic pathways, some dietary nutrients were revealed to play either protective or pathogenic effects on inflammatory diseases through the metabolic reprogramming of tissue macrophages.
The goal of this research topic is to expand the current knowledge regarding the metabolic regulation of macrophages in the context of inflammation. We welcome Original Research articles and Reviews addressing the following problems:
(1) The impacts of macrophage metabolism on the pathological processes of inflammation;
(2) Metabolism-related genes that regulate macrophage functions in inflammation;
(3) Molecular mechanisms underlying the metabolic control of macrophages in inflammation;
(4) Targeting macrophage metabolism in the treatment of inflammatory disorders;
(5) The impact of diet-derived metabolites on macrophage-mediated inflammatory responses.
Please Note: Studies on monocytes or other macrophage-like cells are also suitable for this topic. We do not accept research that only consists of bioinformatics analysis of either public databases or author-generated omics data. Cancer models are out of the scope of this topic despite their close association with inflammation.
Macrophages are a type of innate immune cells with a wide range of tissue distribution, which have profound impacts on a variety of diseases. Due to their extreme functional plasticity, macrophages quickly respond to microenvironmental cues and participate in almost all aspects of inflammation. They are the major sources of pro-inflammatory as well as anti-inflammatory cytokines and serve as crucial bridges between innate and adaptive immunity. In inflamed tissues, the levels of many metabolites undergo dramatic changes, which substantially affect the functions of macrophages. In addition, the altered uptake or utilization of metabolic substrates (e.g. sugars, amino acids, fatty acids, or their metabolic intermediates) by macrophages determines their pro- or anti-inflammatory properties. Besides the endogenous metabolic pathways, some dietary nutrients were revealed to play either protective or pathogenic effects on inflammatory diseases through the metabolic reprogramming of tissue macrophages.
The goal of this research topic is to expand the current knowledge regarding the metabolic regulation of macrophages in the context of inflammation. We welcome Original Research articles and Reviews addressing the following problems:
(1) The impacts of macrophage metabolism on the pathological processes of inflammation;
(2) Metabolism-related genes that regulate macrophage functions in inflammation;
(3) Molecular mechanisms underlying the metabolic control of macrophages in inflammation;
(4) Targeting macrophage metabolism in the treatment of inflammatory disorders;
(5) The impact of diet-derived metabolites on macrophage-mediated inflammatory responses.
Please Note: Studies on monocytes or other macrophage-like cells are also suitable for this topic. We do not accept research that only consists of bioinformatics analysis of either public databases or author-generated omics data. Cancer models are out of the scope of this topic despite their close association with inflammation.
Keywords: Metabolic Regulation, Macrophage, Inflammation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
