About this Research Topic
The goal of this article collection is to promote the reduction of animal use in carcinogenicity studies, both by increasing the availability of relevant evidence, including from New Approach Methods (NAMs) and existing animal toxicology studies, and by encouraging the adoption of current regulatory guidelines and recommendations.
Submissions to this article collection may discuss either the development of clinical or nonclinical evidence for the assessment of carcinogenicity to humans, without conducting long-term studies in animals, or the adoption of existing recommendations that reduce animal use, including by microsampling for toxicokinetics and by minimizing control groups.
Submission type may include:
• original research reports (including brief reports),
• reviews (including systematic and mini reviews),
• methods, and
• editorials, opinions, and perspectives.
For example, submissions may report or discuss molecular biomarkers, genotoxicity, hormonal perturbation, or immune modulation relating to mechanisms of carcinogenicity and human relevance. Submissions should emphasize the use of NAMs that replace new studies in animals or reduce animal use when studies are conducted; however, refinement of existing animal methods may also be discussed, such as those for measuring chronic and sub-chronic toxicity, to increase their utility in carcinogenicity evaluation.
Keywords: Animal testing alternatives, replacement, refinement, reduction, biomarkers, tumor, carcinogenicity tests, Investigational New Drug Application, Neoplasms, rodent bioassay, chronic toxicity tests, weight of evidence, WoE
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.