Acute and Hereditary Coagulation Disorders

Coagulation disorders can have a variety of causes and may lead to either an increased risk of excessive bleeding or an increased risk of thromboembolic events. Both types of coagulation disorders can be life-threatening and require immediate therapy. Major bleeding is often triggered by an acute cause, such as severe trauma or peripartum hemorrhage (PPH) . The high rate of pre-existing intake of anticoagulants, such as DOACS or Vitamin-K antagonists, can also induce or even aggravate bleeding events, for example in cerebral hemorrhage or traumatic brain injury (TBI). Hereditary causes, such as the congenital Factor XIII deficiency or hemophilia, can also trigger a clinically relevant hemorrhage however, hereditary coagulation disorders are more often associated with thromboembolic events.

Therapies for these coagulation disorders are often highly specific and decisions are often made under time-pressure. Therefore, the main goal of this Research Topic is to highlight innovative diagnostic and treatment approaches in the field. There is also an aim to encourage authors in submitting basic research to improve the understanding of the underlying pathophysiological processes.

We encourage researchers to submit articles on but not limited to the following fields:
- Trauma induced hemorrhage
- Cerebral hemorrhage and traumatic brain injury
- Peripartum hemorrhage
- Antagonization of anticoagulants
- Point-of-Care and other diagnostic approaches
- Algorithm based therapies
- Next-generation-Sequencing and new genomic approaches in the diagnostic
- Genetic pre-dispositions and their impact on coagulation disorders
- Rare hereditary coagulation disorders (diagnostic and therapy)

This Research Topic welcomes the following article types: Brief Research Report, Case Report, Clinical Trial, Correction, Editorial, General Commentary, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Study Protocol, Systematic Review.