About this Research Topic
Aging-related diseases, such as musculoskeletal diseases, have a significant negative impact on the elderly’s quality of life. Autologous stem cells have the ability to self-renew and differentiate into specific somatic cells in order to replace senescent cells and keep the body functioning. However, autologous stem cells are diminishing with age. As a result, allogeneic stem cells and their engineering may be used to prevent the onset of aging-related diseases, as well as to improve tissue regeneration and function maintenance, thereby promoting health and longevity. Alternatively, extracellular vesicles (EVs) transport functional biological components and serve as essential messengers for intercellular communication and mediators of cellular functions. As a novel cell-free approach to treat aging-related diseases, EVs released by stem cells show promising regenerative potential. Furthermore, through engineering and modification, EVs are cell-specificity targeted and efficient in delivering functional cargos (i.e., proteins, nucleic acids, and chemicals) for tissue regeneration and rejuvenation.
More research with stem cells and their derived EVs for treating aging-related diseases is always desired, as this may pave the way for their translational applications. In addition, the mechanisms by which stem cells and EVs function for preclinical administration still require further elucidation. Thus understanding the mechanisms and developing innovative stem cell EV-based therapeutic strategies (i.e., cell-free system), as well as their molecular targets, is urgently needed to prevent and treat aging-related diseases.
This Research Topic aims to compile a comprehensive list of Original Research articles, Reviews, and Mini-reviews on various aspects of stem cells, EVs, and the derived strategies for treating aging-related diseases, including essential, translational, and clinical research Subtopics may include but are not limited to：
-Engineering stem cells to treat aging-related diseases;
-Development of in vitro model systems for the production of EVs from stem cells;
-Advances in EV modification and delivery to develop new therapeutic strategies for treating aging-related diseases;
-The roles of stem cells and stem cell-derived EVs in the treatment of aging-related diseases, as well as their underlying mechanisms;
-Stem cells and stem cell-derived EVs in tissue repair and regeneration and their preclinical applications.
Topic Editor Dr. Bin Jiang is employed by, Fibrobiologics, Houston, USA. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
More research with stem cells and their derived EVs for treating aging-related diseases is always desired, as this may pave the way for their translational applications. In addition, the mechanisms by which stem cells and EVs function for preclinical administration still require further elucidation. Thus understanding the mechanisms and developing innovative stem cell EV-based therapeutic strategies (i.e., cell-free system), as well as their molecular targets, is urgently needed to prevent and treat aging-related diseases.
This Research Topic aims to compile a comprehensive list of Original Research articles, Reviews, and Mini-reviews on various aspects of stem cells, EVs, and the derived strategies for treating aging-related diseases, including essential, translational, and clinical research Subtopics may include but are not limited to：
-Engineering stem cells to treat aging-related diseases;
-Development of in vitro model systems for the production of EVs from stem cells;
-Advances in EV modification and delivery to develop new therapeutic strategies for treating aging-related diseases;
-The roles of stem cells and stem cell-derived EVs in the treatment of aging-related diseases, as well as their underlying mechanisms;
-Stem cells and stem cell-derived EVs in tissue repair and regeneration and their preclinical applications.
Topic Editor Dr. Bin Jiang is employed by, Fibrobiologics, Houston, USA. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: Stem cells, aging-related diseases, Exosomes, extracellular vesicles, disease model
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
