Frontiers | Translational Research in Hereditary Spastic Paraplegias: Filling the Diagnosis Gap and Therapeutic Perspectives

Translational Research in Hereditary Spastic Paraplegias: Filling the Diagnosis Gap and Therapeutic Perspectives

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STUDY PROTOCOL

Accepted on 27 Jan 2025

Flexibility, Resistance, Aerobic, Movement Execution (FRAME) training program to improve gait capacity in adults with Hereditary Spastic Paraplegia: protocol for a single-cohort feasibility trial.

Leonardo Boccuni
Marco Bortolini
Cristina Stefan
Valentina Dal Molin
Giacomo Dalla Valle
Andrea Martinuzzi

doi 10.3389/fneur.2025.1441512

ORIGINAL RESEARCH

Published on 13 Aug 2024

Metabolite profile in hereditary spastic paraplegia analyzed using magnetic resonance spectroscopy: a cross-sectional analysis in a longitudinal study

Domenico Montanaro
Marinela Vavla
Francesca Frijia
Alessio Coi
Alessandra Baratto
Rosa Pasquariello
Cristina Stefan
Andrea Martinuzzi

doi 10.3389/fnins.2024.1416093

708 views

ORIGINAL RESEARCH

Published on 07 Jun 2024

Proteomics and lipidomic analysis reveal dysregulated pathways associated with loss of sacsin

Daniele Galatolo
Silvia Rocchiccioli
Nicoletta Di Giorgi
Flavio Dal Canto
Giovanni Signore
Federica Morani
Elisa Ceccherini
Stefano Doccini
Filippo Maria Santorelli

Proteomics and lipidomic analysis reveal dysregulated pathways associated with loss of sacsin

doi 10.3389/fnins.2024.1375299

938 views

ORIGINAL RESEARCH

Published on 16 Feb 2024

Clinically approved immunomodulators ameliorate behavioral changes in a mouse model of hereditary spastic paraplegia type 11

Michaela Hörner
Sandy Popp
Julien Branchu
Giovanni Stevanin
Frédéric Darios
Stephan Klebe
Janos Groh
Rudolf Martini

Clinically approved immunomodulators ameliorate behavioral changes in a mouse model of hereditary spastic paraplegia type 11

doi 10.3389/fnins.2024.1299554

1,835 views
2 citations

REVIEW

Published on 29 Nov 2023

The therapeutic effects of physical treatment for patients with hereditary spastic paraplegia: a narrative review

Armando Di Ludovico
Francesca Ciarelli
Saverio La Bella
Giovanna Scorrano
Francesco Chiarelli
Giovanni Farello

The therapeutic effects of physical treatment for patients with hereditary spastic paraplegia: a narrative review

doi 10.3389/fneur.2023.1292527

3,450 views

ORIGINAL RESEARCH

Published on 22 Sep 2023

Long-term progression of clinician-reported and gait performance outcomes in hereditary spastic paraplegias

Diana Maria Cubillos Arcila
Gustavo Dariva Machado
Valéria Feijó Martins
Vanessa Bielefeldt Leotti
Rebecca Schüle
Leonardo Alexandre Peyré-Tartaruga
Jonas Alex Morales Saute

Long-term progression of clinician-reported and gait performance outcomes in hereditary spastic paraplegias

doi 10.3389/fnins.2023.1226479

2,176 views
1 citation

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Neurodegeneration

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