About this Research Topic
Acute and chronic liver failures, which represent the loss of liver function, occupy the center stage of hepatic disorders as they are connected with a variety of liver diseases including fatty liver disease, cirrhosis, viral hepatitis, hepatocellular carcinoma and hepatic encephalopathy.
The clinical manifestations of liver failures are multifaceted and usually include fatigue, diarrhea, confusion, excess bleeding, and eventually death. In many cases, the only curative treatment option is liver transplantation. Although it is generally accepted that liver failures occur under the influence of miscellaneous factors, the detailed molecular mechanisms of various liver failures and associated diseases have not been fully elucidated. Since acute and chronic liver failures are major causes of morbidity and mortality globally, a detailed understanding of their associated pathogenesis is essential to improve the treatment options and outcomes in the context of limited liver transplantation.
Currently, severe toxic, metabolic, viral, and autoimmune injuries are the mainstream theories regarding the causes of acute and chronic liver failures. Reducing and limiting the influence of relevant precipitating factors, thus, are the main strategies for the treatment of liver failure-associated disorders. Over the last decade, there is also emerging evidence indicating the contribution of aging, mitochondrial damage, cellular senescence, and autophagy inhibition in the development of liver failures.
This research topic will try to shed light on novel research elucidating the molecular and cellular pathogenesis of various liver diseases, as well as relevant intervention strategies. The aim is to bring together the latest findings on the pathogenesis mechanisms of liver failure-associated diseases and to propose future treatment strategies for acute and chronic liver failures.
The Topic Editors encourage researchers to submit Original Researches, Brief Research Reports, Systematic Reviews, Reviews, mini-Reviews, and Clinical Trials relevant to the pathogenesis and management of liver diseases, including, but not limited to the following themes:
1. Pathophysiology, pharmacology and intervention strategies of acute and chronic liver failures.
2. Pathophysiology, pharmacology and intervention strategies of fatty liver diseases.
3. Pathophysiology, pharmacology and intervention strategies of hepatocellular carcinoma.
4. Pathophysiology, pharmacology and intervention strategies of liver disease-associated neurological complications.
The clinical manifestations of liver failures are multifaceted and usually include fatigue, diarrhea, confusion, excess bleeding, and eventually death. In many cases, the only curative treatment option is liver transplantation. Although it is generally accepted that liver failures occur under the influence of miscellaneous factors, the detailed molecular mechanisms of various liver failures and associated diseases have not been fully elucidated. Since acute and chronic liver failures are major causes of morbidity and mortality globally, a detailed understanding of their associated pathogenesis is essential to improve the treatment options and outcomes in the context of limited liver transplantation.
Currently, severe toxic, metabolic, viral, and autoimmune injuries are the mainstream theories regarding the causes of acute and chronic liver failures. Reducing and limiting the influence of relevant precipitating factors, thus, are the main strategies for the treatment of liver failure-associated disorders. Over the last decade, there is also emerging evidence indicating the contribution of aging, mitochondrial damage, cellular senescence, and autophagy inhibition in the development of liver failures.
This research topic will try to shed light on novel research elucidating the molecular and cellular pathogenesis of various liver diseases, as well as relevant intervention strategies. The aim is to bring together the latest findings on the pathogenesis mechanisms of liver failure-associated diseases and to propose future treatment strategies for acute and chronic liver failures.
The Topic Editors encourage researchers to submit Original Researches, Brief Research Reports, Systematic Reviews, Reviews, mini-Reviews, and Clinical Trials relevant to the pathogenesis and management of liver diseases, including, but not limited to the following themes:
1. Pathophysiology, pharmacology and intervention strategies of acute and chronic liver failures.
2. Pathophysiology, pharmacology and intervention strategies of fatty liver diseases.
3. Pathophysiology, pharmacology and intervention strategies of hepatocellular carcinoma.
4. Pathophysiology, pharmacology and intervention strategies of liver disease-associated neurological complications.
Keywords: liver failure, hepatic encephalopathy, fatty liver disease, steatohepatitis, liver cirrhosis, viral hepatitis, hepatocellular carcinoma, pathophysiology, oxidative/nitrosative stress, inflammation, mitochondria, cell death, hepatotoxicity, therapeutic targets, therapy, regenerative medicine
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