About this Research Topic
Flaviviruses are a large group of enveloped, single-stranded, positive-stranded RNA viruses. Common and important pathogenic flaviviruses include Dengue virus, Zika virus, Japanese encephalitis virus, and so on. Outbreaks of these important pathogenic flaviviruses can result in epidemics and pose a global threat to the health and lives of wild animals, livestock and human beings. Flavivirus life circle is strictly confined within the host cell cytoplasm, mainly relying on the host cells to provide energy and biomacromolecules for their replication. Meanwhile, the host cells have also equipped with multiple defense mechanisms in response to viral invasion and infection. Over the years, immune responses to flavivirus infection have attracted much attention, including innate immune and adaptive immune. However, Flaviviruses have also developed various strategies to interfere with host immunity.
An in-depth investigation of the interactions between those important pathogenic flaviviruses and the host, and clarifying the molecular mechanism will contribute to understanding the cellular responses and molecular pathogenesis of flavivirus infections, which are crucial for the development of novel and more effective treatments and prevention strategies.
The main goal of the proposed Research Topic is to bring together the key experimental and theoretical research focusing on the cellular responses to important pathogenic flavivirus and deeply elucidate the replication mechanism and pathogenesis of these viruses-related diseases. We welcome submissions of various types, including Original Research, Brief Research Report, Methods, Opinion, Review, Mini-Review, Perspective, and Hypothesis and Theory that focus on, but are not limited to, the following subtopics:
1. Flavivirus-induced host cells death (apoptosis, necrosis, pyroptosis and so on) and the molecular mechanism
2. Molecular pathogenesis of induced diseases including Japanese encephalitis, Dengue fever, and so on
3. Flavivirus and host immune interaction
4. Protein modifications in Flavivirus infection
5. Cells metabolism in Flavivirus infection
An in-depth investigation of the interactions between those important pathogenic flaviviruses and the host, and clarifying the molecular mechanism will contribute to understanding the cellular responses and molecular pathogenesis of flavivirus infections, which are crucial for the development of novel and more effective treatments and prevention strategies.
The main goal of the proposed Research Topic is to bring together the key experimental and theoretical research focusing on the cellular responses to important pathogenic flavivirus and deeply elucidate the replication mechanism and pathogenesis of these viruses-related diseases. We welcome submissions of various types, including Original Research, Brief Research Report, Methods, Opinion, Review, Mini-Review, Perspective, and Hypothesis and Theory that focus on, but are not limited to, the following subtopics:
1. Flavivirus-induced host cells death (apoptosis, necrosis, pyroptosis and so on) and the molecular mechanism
2. Molecular pathogenesis of induced diseases including Japanese encephalitis, Dengue fever, and so on
3. Flavivirus and host immune interaction
4. Protein modifications in Flavivirus infection
5. Cells metabolism in Flavivirus infection
Keywords: flavivirus, virus-host Interaction, viral pathogenesis, cellular responses
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
