About this Research Topic
B-cell-mediated immunity is classically viewed as part of the antigen-specific adaptive immune system, mainly related to the generation of protective high-affinity antibodies. However, some specialized populations of unconventional B cells exhibit innate sensing properties and produce immunomodulatory cytokines and natural antibodies.
These so-called innate B cells include B1 B cells, marginal zone B cells, and other related B cell subsets which have been described in humans and mice. The phenotypes, localization, and functional properties of innate B cells are clearly distinctive from conventional B cells. Innate B cells are an emerging topic in B cell immunology and new insights into their biology will redefine the role of B lymphocytes beyond their classical adaptive immune tasks. However, the regulation of innate B cell subsets and their physiological roles in health and disease remains to be better understood.
This Research Topic aims to shed light on the latest discoveries and recent advances in innate B cell research. By gaining new insights into the mechanisms of innate B cell function and their physiological relevance, the Topic will pave the way to a more comprehensive understanding of innate B cells and inspire future research in this field. The Research Topic highlights current concepts and hypotheses on the roles of innate B cells in the regulation of normal immune function and disease. Research articles cover exciting new progress in studying their phenotypes, differentiation, function, contributions to disease, and also their therapeutic potential.
We welcome the submission of Original Research, Reviews, and Mini Review articles, Perspectives, Hypotheses, and Theories. The subjects may include, but are not limited to:
• Definition and classification of novel innate B cell subsets, their cellular origins, and nature contrasting the properties of conventional B cells
• Networks of signal transduction pathways that drive the differentiation and activation of innate B cells
• BCR repertoire analysis and the properties of antibodies produced by innate B cells
• Crosstalk between innate B cells and other innate and adoptive immune cells
• Physiological impacts of innate B cells in the context of infection, inflammatory disease, or other pathophysiological conditions
These so-called innate B cells include B1 B cells, marginal zone B cells, and other related B cell subsets which have been described in humans and mice. The phenotypes, localization, and functional properties of innate B cells are clearly distinctive from conventional B cells. Innate B cells are an emerging topic in B cell immunology and new insights into their biology will redefine the role of B lymphocytes beyond their classical adaptive immune tasks. However, the regulation of innate B cell subsets and their physiological roles in health and disease remains to be better understood.
This Research Topic aims to shed light on the latest discoveries and recent advances in innate B cell research. By gaining new insights into the mechanisms of innate B cell function and their physiological relevance, the Topic will pave the way to a more comprehensive understanding of innate B cells and inspire future research in this field. The Research Topic highlights current concepts and hypotheses on the roles of innate B cells in the regulation of normal immune function and disease. Research articles cover exciting new progress in studying their phenotypes, differentiation, function, contributions to disease, and also their therapeutic potential.
This Research Topic focuses on specific B cell populations with innate B cell properties and innate B cell-derived natural antibodies in humans and mice.
We welcome the submission of Original Research, Reviews, and Mini Review articles, Perspectives, Hypotheses, and Theories. The subjects may include, but are not limited to:
• Definition and classification of novel innate B cell subsets, their cellular origins, and nature contrasting the properties of conventional B cells
• Networks of signal transduction pathways that drive the differentiation and activation of innate B cells
• BCR repertoire analysis and the properties of antibodies produced by innate B cells
• Crosstalk between innate B cells and other innate and adoptive immune cells
• Physiological impacts of innate B cells in the context of infection, inflammatory disease, or other pathophysiological conditions
Keywords: Innate B cell subsets, natural antibodies, BCR repertoire, signal transduction, infection, inflammatory disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
