About this Research Topic
Maintaining mobility and independence is a major priority for older adults, and one that requires a threshold level of skeletal muscle function. However, skeletal muscle undergoes several morphological, structural, and functional changes that impair its force-producing capacity. With the number and proportion of older adults projected to drastically increase over the next several decades, a greater understanding of the muscular adaptations to aging and potential therapies to reverse or delay muscular aging is warranted.
The aim of this Research Topic is to identify and disseminate novel, high-quality investigative findings regarding the effects of aging on skeletal muscle. We also aim to update and summarize current knowledge of age-related changes in skeletal muscle, including how and why older adults respond differently to various interventions, relative to young adults. Submissions that examine inter-individual variability within the older adult population are of particular interest.
This Research Topic welcomes basic, translational, applied, and computational research, with the option to submit as one of several article types, including original research, systematic reviews with or without meta-analysis, mini reviews, perspectives, brief research reports, and opinions. Areas to be covered in this Research Topic may include, but are not limited to:
• Cellular and molecular mechanisms
• ‘Omics’ applications (transcriptomics, proteomics, metabolomics, etc)
• Metabolism
• Mitochondrial function
• Muscle function (strength, power, endurance)
• Muscle morphology (size, composition)
• Sarcopenia/Dynapenia
• Mobility and disability
• Co-morbidities associated with loss of skeletal muscle
• Pharmacological and non-pharmacological interventions
The aim of this Research Topic is to identify and disseminate novel, high-quality investigative findings regarding the effects of aging on skeletal muscle. We also aim to update and summarize current knowledge of age-related changes in skeletal muscle, including how and why older adults respond differently to various interventions, relative to young adults. Submissions that examine inter-individual variability within the older adult population are of particular interest.
This Research Topic welcomes basic, translational, applied, and computational research, with the option to submit as one of several article types, including original research, systematic reviews with or without meta-analysis, mini reviews, perspectives, brief research reports, and opinions. Areas to be covered in this Research Topic may include, but are not limited to:
• Cellular and molecular mechanisms
• ‘Omics’ applications (transcriptomics, proteomics, metabolomics, etc)
• Metabolism
• Mitochondrial function
• Muscle function (strength, power, endurance)
• Muscle morphology (size, composition)
• Sarcopenia/Dynapenia
• Mobility and disability
• Co-morbidities associated with loss of skeletal muscle
• Pharmacological and non-pharmacological interventions
Keywords: skeletal muscle, physical function, frailty, sarcopenia
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
