For the heart to supply blood and energy substrate to all the body's organs, a robust level of aerobic metabolism is essential. Mitochondria play a critical role in the growth, control, and energy production of cardiac bioenergetic systems. The production and regulation of reactive oxygen species (ROS), the ...
For the heart to supply blood and energy substrate to all the body's organs, a robust level of aerobic metabolism is essential. Mitochondria play a critical role in the growth, control, and energy production of cardiac bioenergetic systems. The production and regulation of reactive oxygen species (ROS), the buffering of cytosolic calcium ions and the regulation of apoptosis via the mitochondrial permeability transition pore are the four primary biological functions of mitochondria. Adult cardiac mitochondria, comprising approximately 30% of the total cell volume, must continuously generate substantial amounts of ATP via oxidative phosphorylation to sustain contractile activity. To maintain mitochondrial homeostasis, cardiomyocytes have developed well-coordinated quality control systems involving mitochondrial synthesis, mitochondrial dynamics, and mitophagy. The activation of the mitochondrial-permeability transition pore (MPTP), mitochondrial malfunction, and cell death, however, can occur under pathological conditions of uncontrolled ROS production. These conditions can also cause damage to DNA, proteins, and lipids. In fact, oxidative stress and improperly controlled ROS generation have been linked to a variety of cardiac disorders, including cardiac hypertrophy, heart failure, and diabetic cardiomyopathy.
We want to provide a platform for recent research on the physiological and cellular mechanisms that connect mitochondrial disorder, cardiomyopathy, and cardiovascular disease (CVD), as well as the pathophysiology and clinical effects of CVD brought on by abnormal mitochondrial metabolism.
We welcome submissions on the following topics but are not limited to:
- The mechanism of abnormal cardiac ROS.
- Pathophysiological mechanism of mitochondrial cardiomyopathy.
- The roles of mitochondrial disorders in diabetic cardiomyopathy.
- Morphological and functional changes of mitochondria during cardiomyopathy.
- Mitochondrial interaction with endoplasmic reticulum and other organelles during cardiomyopathy.
Keywords:
mitochondria disorders, cardiomyopathy
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.