About this Research Topic
Typically, the biological activities of organic substances are determined by their chemical structures. Although antimicrobials encompass a wide variety of structural motifs, their biosynthetic logic is often highly conserved and can be assigned to several major classes, including polyketides, nonribosomally synthesized peptides (NRPs), ribosomally synthesized and post-translationally modified peptides (RiPPs), terpenoids, and alkaloids. Understanding the biosynthetic mechanisms of diverse metabolic pathways is vital to create novel genetic combinations of biosynthetic genes and thus generating “unnatural” natural molecules in the future, so-called combinatorial biosynthesis attempts. Nowadays, advances and rapid developments in genome sequencing technologies, bioinformatics, and chemical analysis have accelerated the process of genomics-based discovery for previously overlooked natural products. Besides the well-known producers such as bacteria, fungi, and plants, antimicrobial production can also be explored in neglected anaerobic bacteria or other organisms. Further investigation of antimicrobial production in their native communities will not only provide a deeper understanding of their ecological functions but will also lead to the discovery of new antimicrobials.
This research topic focuses on the identification and structural diversification of novel antimicrobials, as well as the study of their mechanisms. Different types of manuscripts will be considered, with the lists of topics, but are not limited to:
1) Discovery of antimicrobials based on bioactivity-guided approaches
2) Discovery of antimicrobials by genomics-based discovery approaches
3) Structural diversification of antimicrobials by synthetic biology or chemo-enzyme approaches
4) Discovery of bioactive antimicrobials by diversity-oriented chemical synthesis
5) Biosynthetic study of antimicrobials
6) Identification of the action and resistance mechanisms of antimicrobials
Keywords: antimicrobial discovery, multiple drug resistance, genome mining, biosynthesis, synthetic biology, antimicrobial target
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