Nitric Oxide (NO), though small and labile, is a potent signaling molecule that plays important roles in both normal physiological function, as well as disease initiation and progression. Both lack and excess NO have been revealed as a contributing factor in pathophysiology in nearly all organs of the body.
The dichotomous effects of NO and reactive nitrogen species (RNS) are often explained by considering the interactions with different targets as a result of concentration and temporal constraints. Endogenous levels of NO range between orders of magnitude, from picomolar to low micromolar. This is attributed respectively to the constitutive endothelial and neuronal NOS isoforms, (eNOS/NOS3 and nNOS/NOS1), and to the Inducible NOS (iNOS/NOS2).
NO concentrations can lead to activation of intracellular signaling pathways, and even being oncogenic. NO can also orchestrate and tune anabolic and catabolic metabolism, including sugar, fatty acid, and amino acid metabolism. Since metabolic and redox mechanisms change dynamically the investigation of the interplay between diseases such as cancer and NO can be challenging. Moreover, NO signaling not only act within the cell but also impact adjacent and distal cells across different spatial and temporal spheres. Therefore, the mechanisms underpinning redox balance in physiology and are of great interest in basic science disciplines as well as for the development of effective therapeutics.
This Research Topic aims to collate compelling research and review pertaining to this important molecule in redox biology that is of interest to researchers in biology, chemistry, chemical biology, medicine, pharmacology, pathology, toxicology, and related disciplines. Herein, we aim to collect and organize recent work describing Integrative Approaches to study NO and RNS in Physiology and Disease. We will focus on (1.) novel strategies and techniques to elucidate their formation and roles of NO and RNS. (2.) The interplay of NO and RNS with other redox species, modulation in health and disease conditions like cancer, COVID 19 and previously unattributed pathologies.
We welcome contributions to this collection in the form of original research, review, and scientific opinionated editorial essays/short communications that pertain to the following themes regarding Nitric Oxide:
• production, chemical biology and sources
• cellular phenotype and signaling
• immunometabolism and tumor microenvironment
• novel methods to characterize or quantify NO and RNS
Dr. Palmieri is serving in her personal capacity. The views expressed are her own and do not necessarily represent the views of the National Institutes of Health or the United States Government.
Nitric Oxide (NO), though small and labile, is a potent signaling molecule that plays important roles in both normal physiological function, as well as disease initiation and progression. Both lack and excess NO have been revealed as a contributing factor in pathophysiology in nearly all organs of the body.
The dichotomous effects of NO and reactive nitrogen species (RNS) are often explained by considering the interactions with different targets as a result of concentration and temporal constraints. Endogenous levels of NO range between orders of magnitude, from picomolar to low micromolar. This is attributed respectively to the constitutive endothelial and neuronal NOS isoforms, (eNOS/NOS3 and nNOS/NOS1), and to the Inducible NOS (iNOS/NOS2).
NO concentrations can lead to activation of intracellular signaling pathways, and even being oncogenic. NO can also orchestrate and tune anabolic and catabolic metabolism, including sugar, fatty acid, and amino acid metabolism. Since metabolic and redox mechanisms change dynamically the investigation of the interplay between diseases such as cancer and NO can be challenging. Moreover, NO signaling not only act within the cell but also impact adjacent and distal cells across different spatial and temporal spheres. Therefore, the mechanisms underpinning redox balance in physiology and are of great interest in basic science disciplines as well as for the development of effective therapeutics.
This Research Topic aims to collate compelling research and review pertaining to this important molecule in redox biology that is of interest to researchers in biology, chemistry, chemical biology, medicine, pharmacology, pathology, toxicology, and related disciplines. Herein, we aim to collect and organize recent work describing Integrative Approaches to study NO and RNS in Physiology and Disease. We will focus on (1.) novel strategies and techniques to elucidate their formation and roles of NO and RNS. (2.) The interplay of NO and RNS with other redox species, modulation in health and disease conditions like cancer, COVID 19 and previously unattributed pathologies.
We welcome contributions to this collection in the form of original research, review, and scientific opinionated editorial essays/short communications that pertain to the following themes regarding Nitric Oxide:
• production, chemical biology and sources
• cellular phenotype and signaling
• immunometabolism and tumor microenvironment
• novel methods to characterize or quantify NO and RNS
Dr. Palmieri is serving in her personal capacity. The views expressed are her own and do not necessarily represent the views of the National Institutes of Health or the United States Government.