About this Research Topic

Background

Environmental factors may affect the epigenetic structure, and the changes can lead to the establishment of wrong epigenetic programs, thus leading to a variety of human diseases, such as tumors, aging, imprint syndrome, immune diseases, central nervous system, and mental development disorders. Both environment and gene are two important determinants of health or disease status. In recent years, great changes have taken place in the way of lifestyle, diet, and life rhythm of human beings and the environment around of human beings. Whether such changes have important contributions to the occurrence and development of human diseases is worth discussing and studying.

This topic will focus on the effect and mechanism of pollution, noise, pressure, unhealthy diet, and other modern living environments on diseases via epigenetic change. And also, aim to explore and define whether those factors can cause epigenetic disorders by changing intestinal metabolites via targeting microflora. And more research confirmation of the effect of those factors on Intergenerational and transgenerational diseases is needed. We encourage multi-omic approaches to reveal the impact of environmental changes on diseases, and research about chromatin remodeling, chromatin accessibility, and intestinal flora of epigenetic disorder will be well received. Papers about new phenomena, new mechanisms, and novel methods of epigenetic disorder will also be well received.

Both article and review are encouraged, and the specific themes are as follows:

• Changes in epigenetic characteristics of cells (including germ cells and early embryos), tissues, and organs caused by the modern living environment (air pollution, noise, pressure, etc.).

• Changes of epigenetic characteristics of cells (including germ cells and early embryos), tissues, and organs caused by modern diet (high fat, high cholesterol, high sugar).

• Effect of intestinal microflora and its metabolites on epigenetic disease.

• Effect of modern lifestyle on the Intergenerational and transgenerational of diseases using animal experiments.

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.

Keywords: Environment, epigenetic, disease, diet, lifestyle

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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