Inflammatory Bowel Disease - A State-of-the-Art and Future Aspects from a Systems Biology Perspective

Inflammatory bowel disease (IBD) is a chronic inflammatory disease as a result of a dysregulated immune response caused by a combination of environmental and genetic factors. The main challenges are the lack of a comprehensible understanding of the inflammatory process and how to detect prognostic and predictive factors for therapeutic approaches at the onset and during the course of the disease.

IBD represents a complex interaction within various biological systems. The goal of this study is to develop a review of the state of the art of systems biology in the context of integrating available transomic IBD data and future aspects of this scientific approach.

A team of international scientists will give an overview of their respective research fields including genetics, epigenetics, proteomics, metabolomics/lipidomics, immunohistochemistry, multimodal molecular imaging, and finally transomics analyses. Based on this set of transomic knowledge the goals of the study will be performed.

At least two review articles have been planned- one on the pathophysiology of IBD and one on predictive and prognostic biomarkers of IBD.

The study will give new interpretations of available data and most likely be beyond the-state-of-the-art of IBD with a special focus on precision medicine in IBD which is one of the most important frontiers in IBD research.