About this Research Topic
With the aging of the population, osteoporosis is becoming one of the most common diseases affecting health, particularly in postmenopausal women. Hip fractures caused by osteoporosis can kill patients directly or indirectly in the short term, posing a significant medical burden on society. Bone is in a dynamic balance of constant absorption and reconstruction, which is highly dependent on energy metabolism. According to research, energy metabolism disorders in osteoclasts can disrupt bone homeostasis, resulting in osteoporosis. The role of osteoclast energy metabolism in the occurrence and progression of osteoporosis has recently become a hot topic, but there is still a lack of systematic and in-depth research. As a result, we are looking forward to learning more about the role of cellular energy metabolism in osteoporosis, which will provide new targets and directions for osteoporosis treatment.
The goal of this Research Topic is to increase our understanding of the molecular and biochemical mechanisms of osteoclast energy metabolism in the occurrence and development of osteoporosis, as well as to stimulate further investigation of potential therapeutic targets, ranging from basic pathological mechanisms to clinical translational therapies. We hereby invite multidisciplinary scholars to contribute to the discussion of this Research Topic in the form of Original Research articles or Reviews.
We encourage authors to focus specifically on the mechanisms underlying the role of osteoclast energy metabolism in osteoporosis. Potential subtopics include, but are not limited to, those listed below:
• Recent advances in the role of osteoclast energy metabolism in osteoporosis;
• Biomarkers of osteoclast energy metabolism disorder in osteoporosis;
• Mitochondrial generation and load level regulation in osteoclasts;
• Mechanisms of hypoxia and oxidative stress affecting energy metabolism of osteoclasts;
• Effects of systemic energy metabolism on energy metabolism of osteoclasts and the development of osteoporosis;
• The role of glycolysis in osteoclast development and activity;
• The role of lipid and amino acid metabolism in bone micro-environment homeostasis;
• New specific drug therapy for osteoporosis from the perspective of glycolysis or oxidative phosphorylation.
The goal of this Research Topic is to increase our understanding of the molecular and biochemical mechanisms of osteoclast energy metabolism in the occurrence and development of osteoporosis, as well as to stimulate further investigation of potential therapeutic targets, ranging from basic pathological mechanisms to clinical translational therapies. We hereby invite multidisciplinary scholars to contribute to the discussion of this Research Topic in the form of Original Research articles or Reviews.
We encourage authors to focus specifically on the mechanisms underlying the role of osteoclast energy metabolism in osteoporosis. Potential subtopics include, but are not limited to, those listed below:
• Recent advances in the role of osteoclast energy metabolism in osteoporosis;
• Biomarkers of osteoclast energy metabolism disorder in osteoporosis;
• Mitochondrial generation and load level regulation in osteoclasts;
• Mechanisms of hypoxia and oxidative stress affecting energy metabolism of osteoclasts;
• Effects of systemic energy metabolism on energy metabolism of osteoclasts and the development of osteoporosis;
• The role of glycolysis in osteoclast development and activity;
• The role of lipid and amino acid metabolism in bone micro-environment homeostasis;
• New specific drug therapy for osteoporosis from the perspective of glycolysis or oxidative phosphorylation.
Keywords: osteoporosis, energy metabolism, therapeutic targets, biochemical mechanism, osteoclast, bone homeostasis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
