About this Research Topic
In this Research Topic, we invite the submission of manuscripts exploring the specific opportunities and challenges for using C. elegans in natural product driven drug discovery, and pharmacodynamics. We invited the submission of manuscripts on pharmacological effects and underlying mechanisms of medicinal plant extracts, metabolites and other natural products using C. elegans, especially the pathological models in C. elegans. The first aim of this Research Topic is to provide a comprehensive understanding of the value of model animal C. elegans in ethnopharmacological research. The second aim of this Research Topic is to highlight the usefulness of established pathological models in the ethnopharmacological study of different aspects of C. elegans.
The scope of this Research Topic includes but is not limited to:
• Natural product driven drug screening and drug discovery using pathological models
• Pharmacological effects and mechanisms of medicinal plant extracts. metabolites, and other natural products
• Identification of biologically active metabolites in medicinal plants and other nature derived medicines like fungi
In particular we encourage MS using this model organism in the are of ethnopharmacology focusing on
• Neurological disease models including different stress models’
• Metabolic diseases and disorders
All the manuscripts submitted to the collection will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here) and specifically MS need to comply with the ConPhyMP standards (https://www.frontiersin.org/articles/10.3389/fphar.2020.00765/full)
Keywords: Pharmacological mechanism, Drug screen, Drug discovery, Caenorhabditis elegans, Neurodegeneration, Neuroprotective, Pathogen infection, Immunity, Aging, Stress, Metabolism
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.