Osteoporosis and Adipokines: the Potential for Future Treatment

Osteoporosis is a condition in which bone mineral density is reduced due to altered bone microstructure which results in increased skeletal fragility and incidence of various types of fractures. One in three women can have osteoporosis after menopause, the incidence of osteoporosis is increasing at an alarming rate. Adipokines such as leptin, adiponectin, chemerin, vaspin, visfatin, omentin-1 and others are involved in bone remodelling. They influence the differentiation and function of two important bone cells osteoblasts and osteoclasts. These adipokines are emerging, as a key player in the complex system that regulates bone metabolism.

The treatment of established osteoporosis is complex and costly. Therefore, it is essential to find out the modifiable risk factors responsible for developing osteoporosis so that in future new treatment strategies can be developed to treat this silent disease. This Research Topic aims to illustrate the critical role of adipokines in the progression and prevention for the disease osteoporosis. This Research Topic is also devoted to finding out the potential therapeutic targets by modulating the level of these adipokines to treat osteoporosis.

We welcome submissions covering, but not limited to, the following aspects:

• Studies related to adipokines and their role in bone metabolism

• Experimental and clinical evidence that links adipokine actions with osteoporosis

• Female researchers involved in bone research are encouraged to submit their proposals

• The positive and negative effects of these adipokines in the microenvironment of bone during the progression and treatment of osteoporosis

• Effective therapeutic strategies about the treatment for osteoporosis through modulation of these adipokines.