Recurrent Pregnancy Loss and Endocrine Dysfunction

Recurrent pregnancy loss (RPL), defined by WHO as three or more consecutive pregnancy losses, bothers 1–5% of couples around the world, significantly impacting their partnership and quality of life. However, the causes for the occurrence of RPL are complicated and mysterious. Over the years, many factors have been described, studied, and criticized, including structural uterine abnormalities, genetic diseases, autoimmune disorders, endocrine dysfunction, and so on. Among these, endocrine factors, especially thyroid dysfunction, PCOS, insulin resistance, and hyperprolactinemia, accounts for an important part and can be easily screened and identified with simple tests. Nevertheless, there are still many gaps in the exact mechanisms underlying the pathogenesis of endocrine-related PRL, as well as the strategy and value of treatment for these endocrine dysfunctions.

This Research Topic aims to present new findings on the pathogenesis of endocrine-related PRL. We hope to better understand how endocrine dysfunction leads to PRL and then find potential therapeutic targets. It also aims to present new evidence on the treatment for endocrine-related PRL, providing guidance for clinical strategies.

The current Research Topic encourages Original Research, Reviews, or other accepted article types relating but not limited to:
• Thyroid dysfunction and the pathogenesis of RPL;
• RPL in patients with PCOS;
• Insulin resistance related RPL;
• Role of hyperprolactinemia in RPL;
• The strategy and value of treatment on the endocrine dysfunction in patients with PRL;
• Development of models to evaluate endocrine-related PRL;
• Evolution of detection or diagnosis methods for endocrine-related PRL.