About this Research Topic
Cell death is an important physiological or pathological phenomenon in the life process of multicellular organisms. Cell death includes active programmed cell death (including apoptosis, ferroptosis, cuproptosis, pyroptosis, etc.) and passive nonprogrammed cell death (necrosis). Since the upregulated inhibitors of apoptosis protein in cells may limit the therapeutic outcome, more studies focus on nonapoptotic cell death to overcome the bottleneck of apoptosis.
There is emerging evidence that nanomaterials with intrinsic properties have the potential in triggering ferroptosis, cuproptosis, pyroptosis, or necrosis, contributing to enhanced therapeutic benefits and reduced side effects. Thus, understanding the interaction between nanomaterials and nonapoptotic cell death plays an important role in the management of different diseases.
Nanomaterials capable of different surface-to-volume ratios and surface functionalization demonstrate different biological effects and biomedical applications. For example, tea polyphenols nanoparticles can block pyroptosis via scavenging radical species, while K3ZrF7:Yb/Er upconversion nanoparticles were regarded as pyroptosis inducers for cancer immunotherapy. Moreover, some specific nanomaterials may exhibit a broad range of thermal conversion, photodynamic or theranostic properties for diagnosis and disease treatments. For example, VB12-Sericin-PBLG-IR780 nanomicelles were assembled to trigger NLRP3/Caspase-1/gasdermin D (GSDMD)-dependent pyroptosis by photothermal /photodynamic effect. However, how different nanomaterials with different nanostructures determine nonapoptotic cell death hadn’t been figured out. Based on these aspects, this research topic aims to highlight original research, review articles, and perspectives involving the design and applications of nanomaterials targeting nonapoptotic cell death. In addition, we hope to establish fruitful cross-talk between different scientific areas. With an in-depth understanding of the relationship between nanostructure and function, "precision medicine" with specific clinical implications and challenges can be well-addressed by newly developed nanomaterials.
This research topic welcomes submissions addressing but not limited to the following topics:
• Synthesis and characterization of novel nanomaterials for regulating nonapoptotic cell death;
• Application of nano drugs for inducing/inhibiting nonapoptotic cell death in different kinds of diseases;
• Mechanism of nanoscale drug delivery systems for regulating nonapoptotic cell death;
• Biosafety of nonapoptotic cell death inducer/inhibitor with nano-sized morphology;
• Recent advances in nanoplatforms mediating nonapoptotic cell death
There is emerging evidence that nanomaterials with intrinsic properties have the potential in triggering ferroptosis, cuproptosis, pyroptosis, or necrosis, contributing to enhanced therapeutic benefits and reduced side effects. Thus, understanding the interaction between nanomaterials and nonapoptotic cell death plays an important role in the management of different diseases.
Nanomaterials capable of different surface-to-volume ratios and surface functionalization demonstrate different biological effects and biomedical applications. For example, tea polyphenols nanoparticles can block pyroptosis via scavenging radical species, while K3ZrF7:Yb/Er upconversion nanoparticles were regarded as pyroptosis inducers for cancer immunotherapy. Moreover, some specific nanomaterials may exhibit a broad range of thermal conversion, photodynamic or theranostic properties for diagnosis and disease treatments. For example, VB12-Sericin-PBLG-IR780 nanomicelles were assembled to trigger NLRP3/Caspase-1/gasdermin D (GSDMD)-dependent pyroptosis by photothermal /photodynamic effect. However, how different nanomaterials with different nanostructures determine nonapoptotic cell death hadn’t been figured out. Based on these aspects, this research topic aims to highlight original research, review articles, and perspectives involving the design and applications of nanomaterials targeting nonapoptotic cell death. In addition, we hope to establish fruitful cross-talk between different scientific areas. With an in-depth understanding of the relationship between nanostructure and function, "precision medicine" with specific clinical implications and challenges can be well-addressed by newly developed nanomaterials.
This research topic welcomes submissions addressing but not limited to the following topics:
• Synthesis and characterization of novel nanomaterials for regulating nonapoptotic cell death;
• Application of nano drugs for inducing/inhibiting nonapoptotic cell death in different kinds of diseases;
• Mechanism of nanoscale drug delivery systems for regulating nonapoptotic cell death;
• Biosafety of nonapoptotic cell death inducer/inhibitor with nano-sized morphology;
• Recent advances in nanoplatforms mediating nonapoptotic cell death
Keywords: nanomaterials, nonapoptotic cell death, pyroptosis, ferroptosis, necrosis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
