About this Research Topic
Immunosenescence, known as the remodeling of immune system with age, contributes significantly to reduced efficacy of vaccination, increased susceptibility to infections, reduced immune surveillance potentially contributing to increased cancer incidence and systemic chronic inflammation. Increasing numbers of elderly transplant recipients and a growing demand for organs from older donors impose pressing challenges on transplantation medicine. Older organs display an untapped potential to face the shortness of donor organ supply in transplantation but at the same time are discarded more frequently. It derives from an increased immunogenicity, leading to accelerating ischemia reperfusion injury and allo-immune responses. The recipient immune system in turn, undergoes significant and continuous modifications in parallel to aging. However, the impact of aging-related immune system remodeling during alloimmune responses are still under investigation. More importantly, the significance of age-specific aspects of immunosuppressive therapy in older patients have been recognized recently.
Delineating critical characteristics of immunosenescence during alloimmune responses from both donor and recipient sides in transplantation may thus aid to develop novel age-specific therapies to improve transplant outcomes and allow to modulate conservative immunosuppressive regimens.
We therefore welcome authors to submit Original Research, Reviews, Mini Reviews, and Clinical Trial articles focusing on the following subtopics:
- The role of immunosenescence in clinical solid organ transplantation
- The role of immunosenescence on alloimmune responses and graft rejection pathophysiology
- The impact of immunosenescence on T, NK and B cell immunity implicated in organ transplantation
- Exploring diagnostic and therapeutic approaches to target immunosenescence and cellular senescence in transplantation
- The relevance of immunosenescence for immunosuppression
- The impact of immunosuppression on cellular senescence
- The interaction of immunosenescence and cellular senescence in alloimmune responses.
- Drawing potential interactions of an aging immune system and its impact on transplant immunology
Delineating critical characteristics of immunosenescence during alloimmune responses from both donor and recipient sides in transplantation may thus aid to develop novel age-specific therapies to improve transplant outcomes and allow to modulate conservative immunosuppressive regimens.
We therefore welcome authors to submit Original Research, Reviews, Mini Reviews, and Clinical Trial articles focusing on the following subtopics:
- The role of immunosenescence in clinical solid organ transplantation
- The role of immunosenescence on alloimmune responses and graft rejection pathophysiology
- The impact of immunosenescence on T, NK and B cell immunity implicated in organ transplantation
- Exploring diagnostic and therapeutic approaches to target immunosenescence and cellular senescence in transplantation
- The relevance of immunosenescence for immunosuppression
- The impact of immunosuppression on cellular senescence
- The interaction of immunosenescence and cellular senescence in alloimmune responses.
- Drawing potential interactions of an aging immune system and its impact on transplant immunology
Keywords: Immunosenescence, Organ Transplantation, Cellular Senescence, Aging, Alloimmunity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
