About this Research Topic
This Research Topic aims to highlight studies that focus on better understanding the relationships between neuropsychiatric symptoms and neurodegenerative disease, their trajectories, and the molecular mechanisms underlying neuropsychiatric symptoms in ADRD, in order to improve the earlier identification and treatment of these symptoms in individuals with Alzheimer’s disease or related dementias. Our goal is to promote discussion on the development of tools to diagnose neurodegenerative diseases from early neuropsychiatric manifestations, on the underlying structural and functional circuits and the molecular players which may be targeted for developing personalized treatments and interventions tailored to the specific stages of the neuropsychiatric symptoms and ADRD. We also wish to shed light on research addressing the culture-bound syndrome related to neuropsychiatric symptoms and their relationship with neurodegenerative disease states. With this Research Topic, we hope to promote the finding of low-cost measures to help quickly and effectively diagnose and treat neurodegenerative processes and associated neuropsychiatric symptoms.
We welcome the submission of different types of manuscripts (Original Research articles, Reviews etc.) that focus on, but are not limited to, the following:
- Longitudinal studies of neuropsychiatric symptoms across preclinical and clinical stages of neurodegenerative disease
- Comparison of neuropsychiatric symptoms across different dementia syndromes
- Innovative approaches to assess neuropsychiatric symptoms in preclinical disease stages and dementia syndromes and their prognostic relationship with preclinical and clinical stages of neurodegenerative disease
- Functional and structural neuroimaging studies of neuropsychiatric symptomatology in both preclinical and symptomatic disease
- Omics studies such as genomics, RNA-sequencing, and methylation profiles of psychiatric traits and ADRD
- Treatment and intervention for neuropsychiatric symptoms across the continuum of cognitive impairment and the impact of those treatments on the progression of the dementia
- Cross-cultural examinations of neuropsychiatric symptoms in Alzheimer’s disease and related dementias
Dr. Foteini Christidi acts as Field Expert in Neuropsychological and Advanced Neuroimaging Techniques at Advantis Medical Imaging. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: Alzheimer's disease, dementia, psychiatric symptoms, neuroimaging, genomics, transcriptomics, epigenetics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.