Treatment and Prognostic Assessment of Liver Cirrhosis and Its Complications

About 2 million deaths worldwide annually are attributable to liver diseases. Among them, half die from cirrhosis and the other half from viral hepatitis and hepatocellular carcinoma. When patients with liver cirrhosis develop to the decompensated stage, a variety of complications will occur, such as ascites, spontaneous bacterial peritonitis, variceal bleeding, hepatic encephalopathy, hepatorenal syndrome, and jaundice, which will seriously affect the patient's quality of life with reduced survival time and increased socioeconomic burden. Therefore, early assessment and clinical management of cirrhosis and its complications are crucial for both clinicians and patients.

This Research Topic aims to call for high-quality papers regarding the treatment and prognostic assessment of liver cirrhosis and its complications focusing on, but not limited to, the followings:

- Pathogenesis of liver cirrhosis;
- Imaging assessment of liver cirrhosis;
- Prognostic assessment of liver cirrhosis and its complication;
- Role of nutritional status, portal hemodynamic status, cardiac function, and renal function in the prognostic assessment of liver cirrhosis;
- Impact of therapeutic options on the prognosis of liver cirrhosis, such as direct antiviral drugs, statins, anticoagulants, non-selective beta-blockers in ascites, human albumin infusions, and endoscopic variceal treatment, etc.;
- Assessment and management of ascites, upper gastrointestinal bleeding, hepatic encephalopathy, hepatorenal syndrome, hypersplenism, portal vein thrombosis, hepatocellular carcinoma, and other complications in liver cirrhosis;
- Invasive surgery for the treatment and prognosis of liver cirrhosis and its complications, such as endoscopy, transjugular intrahepatic portosystemic shunt, and liver transplantation.