Coronary artery disease (CAD) is a serious health problem worldwide. Atherosclerosis is the primary pathological change of CAD and could lead to the occlusion of coronary artery. Inflammation, oxidative stress, and lipid metabolism disorders contribute to the development of atherosclerosis. Epicardial adipose ...
Coronary artery disease (CAD) is a serious health problem worldwide. Atherosclerosis is the primary pathological change of CAD and could lead to the occlusion of coronary artery. Inflammation, oxidative stress, and lipid metabolism disorders contribute to the development of atherosclerosis. Epicardial adipose tissue (EAT) is directly connected with cardiomyocytes and the adventitia of the coronary artery without fascia boundaries. EAT is regarded as an endocrine tissue which could secret a variety of adipocytokines such as adiponectin, leptin, and omentin-1. Early research has found that EAT from patients with CAD is infiltrated by immune cells like macrophage and T cell, and that EAT is one of the inflammatory sources of CAD. Recent research has focused on the role of adipocytokines and demonstrated that the dysregulation of adipocytokines is closely associated with the development and progression of CAD. Further investigation in the relationship between EAT and CAD would provide insight for the search of biomarker and therapeutics target for CAD.
In this Research Topic, we would like to create a forum for current advances on the cellular and physiological mechanisms linking EAT, adipocytokines, and CAD, the detection of EAT by multimodality imaging, as well as EAT-related biomarker and therapeutics target for CAD.
We welcome submissions of Original Research, Review, and Systematic Reviews on the following subtopics, but are not limited to:
- Advances on cellular and physiological mechanisms linking EAT, adipocytokines, and CAD
- New methods to detect or measure the volume and thickness of EAT
- Exploration in the relationship between the imaging features of EAT and the structure and function of EAT
- New animal models for EAT and CAD research
- Identification of EAT-related biomarker and therapeutics target for CAD
Keywords:
epicardial adipose tissue, coronary artery disease, biomarker, therapeutic target, adipocytokine
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.