About this Research Topic
The Peripheral Nervous System represents the external portion of the Nervous System and, as such, has been subject to little research compared with the Central Nervous System. The research in this area has focused on pathologic conditions, including rare congenital diseases like Charcot-Marie-Tooth, pain disorders like allodynia, and degenerative diseases including diabetic neuropathy. Recently, demyelinating diseases, particularly multiple sclerosis, have gained public attention not only on a scientific level but also regarding the open discussion about the right to the decision of one's own death, defined as euthanasia.
These diseases currently have a poor prognosis, mainly regarding morbidity, but also with mortality and other indicators of quality of life. The development of novel targeted therapies focused on the cellular/molecular level seems, thus, imperative to improve patients´ health.
Currently, most of these diseases have nonspecific treatment options, generally without healing ability, and are related to little extensions of the relapse intervals. New cutting-edge treatments are required to improve the quality of life of patients with peripheral neuropathies.
For this purpose, new research related to the molecular mechanisms underlying different pathological conditions of the Peripheral Nervous System is desired. The desirable objective is to contribute to a better understanding of various pathologies related, for example, to the demyelinization processes, pain mechanisms, or autonomic modulation. The immune-mediated mechanisms related to peripheral neuropathies are also a matter of this Research Topic.
This Research Topic aims to collect the most recent insights into basic, clinical, and translational research regarding mechanisms behind different peripheral neuropathies. The scope of the research includes this way, studies with novel basic, diagnostic or therapeutic approaches that can result in a better understanding of these pathologies, including, motor neuropathies, sensory neuropathies, autonomic nerve neuropathies, and combination neuropathies.
Papers about demyelinating diseases and degenerative neuropathies are highly desired, but papers concerning pain sensation and the alterations in myelinization would be highly regarded too. Furthermore, manuscripts addressing different pathological conditions of the enteric nervous system will be considered. Papers regarding autonomic neuropathies, including hyperhidrosis or anhydrosis, are also welcome.
These diseases currently have a poor prognosis, mainly regarding morbidity, but also with mortality and other indicators of quality of life. The development of novel targeted therapies focused on the cellular/molecular level seems, thus, imperative to improve patients´ health.
Currently, most of these diseases have nonspecific treatment options, generally without healing ability, and are related to little extensions of the relapse intervals. New cutting-edge treatments are required to improve the quality of life of patients with peripheral neuropathies.
For this purpose, new research related to the molecular mechanisms underlying different pathological conditions of the Peripheral Nervous System is desired. The desirable objective is to contribute to a better understanding of various pathologies related, for example, to the demyelinization processes, pain mechanisms, or autonomic modulation. The immune-mediated mechanisms related to peripheral neuropathies are also a matter of this Research Topic.
This Research Topic aims to collect the most recent insights into basic, clinical, and translational research regarding mechanisms behind different peripheral neuropathies. The scope of the research includes this way, studies with novel basic, diagnostic or therapeutic approaches that can result in a better understanding of these pathologies, including, motor neuropathies, sensory neuropathies, autonomic nerve neuropathies, and combination neuropathies.
Papers about demyelinating diseases and degenerative neuropathies are highly desired, but papers concerning pain sensation and the alterations in myelinization would be highly regarded too. Furthermore, manuscripts addressing different pathological conditions of the enteric nervous system will be considered. Papers regarding autonomic neuropathies, including hyperhidrosis or anhydrosis, are also welcome.
Keywords: Peripheral Nervous System, Peripheral neuropathies, Charcot-Marie-Tooth disease, Pain, Hyperesthesia
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
