About this Research Topic
The main types of brain cells are the glial cells such as astrocytes, oligodendrocytes, and microglia and the interaction of the glial cell referred to as the astrocyte with the neuron are essential to maintain neuron life span and prevent neurodegenerative disease. Epigenetic modifications that effect brain cell interactions alter cellular chromatin structure, DNA methylation and histone modifications determine the aging processes of the brain. The literature reports that research on epigenetic changes during healthy ageing and pathological conditions in the brain is increasing and epigenetic research is required to reverse accelerated brain aging and neurodegeneration.
The role of specific genes that are involved in epigenetics are sensitive to nutritional regulation and oxidative stress that can result from changes in cellular chromatin structure, DNA methylation and histone modifications with relevance to aging neuroscience. Epigenetic modification in specific cells such as the brain, adipose tissue and liver are more sensitive than other tissues. These epigenetic modifications induced by unhealthy diets or environmental xenobiotics may involve genes such as Sirtuin 1 (Sirt 1) that alter gene expression in the brain with effects on peripheral organ function that determine the survival of cells in various tissues with accelerated aging and neurodegeneration. Genes such as Sirt 1 may now be considered as a control gene that is critical for epigenetic research and neuroscience. The epigenetics of brain aging and neuroscience is now under considerable experimental research and critical research is required with relevance to epigenetic genes, enhances and modifications that control the aging of the brain and accelerated neurodegeneration. Scientific research in epigenetic reprogramming to control neuron senescence and apoptosis and to promote neuron survival is required to improve brain cell interactions with relevance to the aging process and neuroscience.
Recent advances have contributed to our understanding of the epigenetics of brain aging although there is still much to be uncovered. This Research Topic will be used as a platform to shine a light on the latest neurological research that investigates the relationship between epigenetics and brain aging including epigenetic reprogramming and control of senescence.
Topics may include but are not limited to:
• Lifestyle influences on the epigenetics of brain aging including diet, exercise vs sedentary behavior, and stress levels
• Senescence control, neurodegeneration, and brain aging mediated by epigenetic reprogramming
• Epigenetics as a preventative measure against brain aging and neurodegeneration
• Reversal of age-related neurological damage and disease
• The role of epigenetic biomarkers (e.g., DNA methylation, histone modifications, non-coding RNAs) and their association with neurodegenerative disease and cognitive decline
The role of specific genes that are involved in epigenetics are sensitive to nutritional regulation and oxidative stress that can result from changes in cellular chromatin structure, DNA methylation and histone modifications with relevance to aging neuroscience. Epigenetic modification in specific cells such as the brain, adipose tissue and liver are more sensitive than other tissues. These epigenetic modifications induced by unhealthy diets or environmental xenobiotics may involve genes such as Sirtuin 1 (Sirt 1) that alter gene expression in the brain with effects on peripheral organ function that determine the survival of cells in various tissues with accelerated aging and neurodegeneration. Genes such as Sirt 1 may now be considered as a control gene that is critical for epigenetic research and neuroscience. The epigenetics of brain aging and neuroscience is now under considerable experimental research and critical research is required with relevance to epigenetic genes, enhances and modifications that control the aging of the brain and accelerated neurodegeneration. Scientific research in epigenetic reprogramming to control neuron senescence and apoptosis and to promote neuron survival is required to improve brain cell interactions with relevance to the aging process and neuroscience.
Recent advances have contributed to our understanding of the epigenetics of brain aging although there is still much to be uncovered. This Research Topic will be used as a platform to shine a light on the latest neurological research that investigates the relationship between epigenetics and brain aging including epigenetic reprogramming and control of senescence.
Topics may include but are not limited to:
• Lifestyle influences on the epigenetics of brain aging including diet, exercise vs sedentary behavior, and stress levels
• Senescence control, neurodegeneration, and brain aging mediated by epigenetic reprogramming
• Epigenetics as a preventative measure against brain aging and neurodegeneration
• Reversal of age-related neurological damage and disease
• The role of epigenetic biomarkers (e.g., DNA methylation, histone modifications, non-coding RNAs) and their association with neurodegenerative disease and cognitive decline
Keywords: Epigenetics, senescence control, lifestyle influences, apoptosis
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