Cell death programs in the pathogenesis of heart disease

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Background

Cell death has been implicated in the pathogenesis of multiple forms of heart disease such as myocardial infarction, myocarditis, cardiomyopathy, drug-induced cardiotoxicity, and heart failure of diverse etiologies. In addition to apoptosis, a number of other death programs have recently emerged, including mitochondria-mediated necrosis, death receptor-mediated necrosis (necroptosis), ferroptosis, pyroptosis, parthanatos, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, and other regulated cell death processes. Given cardiac cell death plays a key role in acute cardiac injury and chronic disease, increased knowledge in this area is crucial to advance our mechanistic understanding and develop novel therapeutic strategies.

The goal of this Research Topic is to understand molecular and cellular mechanisms of various cell death programs in cardiac cells and their roles in cardiac homeostasis and disease pathogenesis. How cell death is regulated in the setting of heart disease is incompletely understood, especially the newly discovered non-apoptotic cell death pathways. Further delineation of these cell death pathways that contribute to heart disease can be achieved by molecular and cellular studies as well as in vivo studies using animal models of heart disease.

The scope of this Research Topic covers studies on cardiac cell death and the role of various cell death programs in cardiac physiology and disease, ranging from molecular and cell biology to animal models of heart disease and preclinical studies. Research papers, review articles as well as short communications are welcome.

Specific topics of this collection include:
1. Cell death mechanisms in cardiac myocytes and non-myocytes.
2. Role of cell death in cardiac homeostasis and remodeling.
3. Genetic or pharmacologic interventions targeting cell death pathways.
4. Animal models of cardiac cell death.

Keywords: cell death, cardiomyocytes, cardiac fibroblasts, myocardial injury, cardiac remodeling

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