About this Research Topic
Many traditional risk factors are shared between kidney and cardiovascular disease, such as atherosclerosis, hypertension, diabetes, and many biochemical mechanisms negatively influence each other when one of the two organs is dysfunctional, or insufficiency is established. Moreover, various systemic acute and chronic conditions such as sepsis, diabetes, amyloidosis, systemic lupus erythematosus (SLE), sarcoidosis, and connective tissue disorders could affect the kidney and cardiovascular system with shared etiopathogenic mechanisms and immunologic bio-molecular effectors.
Also, inherited disease (e.g., Fabry disease) or drug toxicity frequently affect the heart and kidney (e.g., NSAIDs)
Additionally, in COVID-19, the dysregulation of the immune system leads to multisystem inflammatory syndrome (MIS) more frequently in children (MIS-C) with the possible co-existence of kidney and heart involvement.
The goal of this Research Topic is to gain understanding the shared mechanisms of damage between the heart and kidney is essential to finding potential target therapies or management strategies.
We encourage the submission of original articles, reviews, systematic reviews/metanalysis and brief reports. Also, case reports with a brief review of the literature or with a particular focus on immunological investigations or specific therapies could be accepted
Also, inherited disease (e.g., Fabry disease) or drug toxicity frequently affect the heart and kidney (e.g., NSAIDs)
Additionally, in COVID-19, the dysregulation of the immune system leads to multisystem inflammatory syndrome (MIS) more frequently in children (MIS-C) with the possible co-existence of kidney and heart involvement.
The goal of this Research Topic is to gain understanding the shared mechanisms of damage between the heart and kidney is essential to finding potential target therapies or management strategies.
We encourage the submission of original articles, reviews, systematic reviews/metanalysis and brief reports. Also, case reports with a brief review of the literature or with a particular focus on immunological investigations or specific therapies could be accepted
Keywords: Kidney, cardiovascular, cardiorenal syndrome, systemic disease, inherited disease, immunology, systemic lupus erythematosus, sarcoidosis, amiloidosis, COVID-19, multisystem inflammatory syndrome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
