Although COVID-19 full prime vaccination generates immunity against severe and life-threatening infections, there are still cases of breakthrough infections. This might be due to several causes — such as the fact that full prime vaccination might not generate enough immunity; that immunity wanes over time; or that the elderly, immunocompromised, transplant recipients and people with underlying diseases could suffer severe infections regardless of vaccination. Moreover, emerging new variants of concern (such as Delta or Omicron) that are highly infective and evade immunity could increase breakthrough infection.
Booster shots could increase immunity and reduce the likelihood of having severe COVID and post-COVID-19 (long COVID). Immunocompromised or transplant recipients could generate immunity after booster shots even if they did not develop immunity after full prime. Moreover, booster shots not only protect vaccinated individuals, but they could also reduce the impact on lifestyle, public health and economics.
This research topic aims to focus on the effect of COVID-19 booster shots and the evidence seen in animal models, clinical trials, real-world evidence, and systematic reviews.
We welcome submissions of Original Research, Mini Review, Systematic Reviews, Policy and Practice Reviews, Clinical Trials, Perspectives, Commentaries, Policy Brief and Brief Research Reports on the following subtopics:
- COVID-19 booster vaccination immunogenicity.
- COVID-19 booster vaccination efficacy and effectiveness.
- COVID-19 booster vaccination in children.
- COVID-19 boosters with new-generation vaccines (non-ancestral strain or first generation)
- COVID-19 booster vaccination in vaccine failure, transplant-recipients or immunocompromised
- Hybrid immunity in booster vaccines.
- Booster vaccination strategy.
- Effect of the breakthrough infection in COVID-19 booster dose vaccines compared to unvaccinated people or people who have not received a booster shot.
- Impact of COVID-19 booster vaccination on public health and policy.
- Heterologous regimes
- Vaccine hesitancy
Although COVID-19 full prime vaccination generates immunity against severe and life-threatening infections, there are still cases of breakthrough infections. This might be due to several causes — such as the fact that full prime vaccination might not generate enough immunity; that immunity wanes over time; or that the elderly, immunocompromised, transplant recipients and people with underlying diseases could suffer severe infections regardless of vaccination. Moreover, emerging new variants of concern (such as Delta or Omicron) that are highly infective and evade immunity could increase breakthrough infection.
Booster shots could increase immunity and reduce the likelihood of having severe COVID and post-COVID-19 (long COVID). Immunocompromised or transplant recipients could generate immunity after booster shots even if they did not develop immunity after full prime. Moreover, booster shots not only protect vaccinated individuals, but they could also reduce the impact on lifestyle, public health and economics.
This research topic aims to focus on the effect of COVID-19 booster shots and the evidence seen in animal models, clinical trials, real-world evidence, and systematic reviews.
We welcome submissions of Original Research, Mini Review, Systematic Reviews, Policy and Practice Reviews, Clinical Trials, Perspectives, Commentaries, Policy Brief and Brief Research Reports on the following subtopics:
- COVID-19 booster vaccination immunogenicity.
- COVID-19 booster vaccination efficacy and effectiveness.
- COVID-19 booster vaccination in children.
- COVID-19 boosters with new-generation vaccines (non-ancestral strain or first generation)
- COVID-19 booster vaccination in vaccine failure, transplant-recipients or immunocompromised
- Hybrid immunity in booster vaccines.
- Booster vaccination strategy.
- Effect of the breakthrough infection in COVID-19 booster dose vaccines compared to unvaccinated people or people who have not received a booster shot.
- Impact of COVID-19 booster vaccination on public health and policy.
- Heterologous regimes
- Vaccine hesitancy