About this Research Topic
Atherosclerotic carotid artery disease which narrows the internal carotid artery by 50% or more according to NASCET criteria is found in 15–20% of patients who present with ischaemic stroke or transient ischaemic attack. The management of this pathology includes medical treatment and recanalization through surgery or endovascular treatment. However, when the presentation escapes secondary prevention and occurs in the context of an acute ischemic stroke (tandem lesion), it is the cause of 10-15% of mechanical thrombectomies in the anterior territory. The management of carotid pathology in both cases associates diagnostic and therapeutic challenges yet to be solved.
The prevalence of stroke due to carotid stenosis in the adult population is up to 10%-15%, contributing to severe morbidity and mortality worldwide. Ischemic stroke recurrence and incidence due to carotid disease can be reduced with the use of intensive medical treatment and endovascular (stent) or surgery (endarterectomy) management. Apart from procedural complications, both treatments are equally effective in preventing stroke and recurrent severe carotid stenosis in the medium-to-long term. However, with advances in medical therapy, the benefit of invasive therapy has become uncertain.
In addition, carotid stenosis can present in the acute stroke setting, requiring the use of endovascular therapy for extra, intracranial, or both recanalization, as is the case with tandem lesions, which accounts for 10-15% of large vessel occlusions undergoing mechanical thrombectomy. Currently, the management of the tandem lesion associates medical raises that are yet to be agreed upon. The use of cervical stents in the acute phase and the need for antiplatelet therapy remain to be defined, given the associated bleeding risk. That is why carotid stenosis represents a wide field of study from secondary prevention to its management in the acute phase. The aim of this research topic is to improve knowledge in symptomatic carotid stenosis diagnosis and treatment, whether the management is during an elective intervention or in the acute phase of mechanical thrombectomy.
The scope of this research topic includes medical and invasive (surgery, stenting) approaches to carotid stenosis, including the selection of candidate patients for each therapeutic option, complications and clinical results associated with each technique, as well as antiaggregant management in scheduled interventions or during mechanical thrombectomy, clinical results of tandem lesions or any aspect that helps us to improve the management and prognosis of this cause of ischemic stroke. A prospective registry data, systematic review, or even a pilot trial would be particularly welcome.
We encourage the submission of original research articles, methods, clinical trials, study protocols, perspectives, reviews, and mini-reviews (excluding case reports and case series) addressing the above-mentioned topics, but not limited to these topics.
Potential for submissions would be:
Symptomatic carotid artery management
Hyperperfusion syndrome
Carotid reocclusion in acute setting
Antiplatelet therapy in acute ischemic stroke due to tandem lesion
Carotid restenosis
Carotid artery disease prevention
The prevalence of stroke due to carotid stenosis in the adult population is up to 10%-15%, contributing to severe morbidity and mortality worldwide. Ischemic stroke recurrence and incidence due to carotid disease can be reduced with the use of intensive medical treatment and endovascular (stent) or surgery (endarterectomy) management. Apart from procedural complications, both treatments are equally effective in preventing stroke and recurrent severe carotid stenosis in the medium-to-long term. However, with advances in medical therapy, the benefit of invasive therapy has become uncertain.
In addition, carotid stenosis can present in the acute stroke setting, requiring the use of endovascular therapy for extra, intracranial, or both recanalization, as is the case with tandem lesions, which accounts for 10-15% of large vessel occlusions undergoing mechanical thrombectomy. Currently, the management of the tandem lesion associates medical raises that are yet to be agreed upon. The use of cervical stents in the acute phase and the need for antiplatelet therapy remain to be defined, given the associated bleeding risk. That is why carotid stenosis represents a wide field of study from secondary prevention to its management in the acute phase. The aim of this research topic is to improve knowledge in symptomatic carotid stenosis diagnosis and treatment, whether the management is during an elective intervention or in the acute phase of mechanical thrombectomy.
The scope of this research topic includes medical and invasive (surgery, stenting) approaches to carotid stenosis, including the selection of candidate patients for each therapeutic option, complications and clinical results associated with each technique, as well as antiaggregant management in scheduled interventions or during mechanical thrombectomy, clinical results of tandem lesions or any aspect that helps us to improve the management and prognosis of this cause of ischemic stroke. A prospective registry data, systematic review, or even a pilot trial would be particularly welcome.
We encourage the submission of original research articles, methods, clinical trials, study protocols, perspectives, reviews, and mini-reviews (excluding case reports and case series) addressing the above-mentioned topics, but not limited to these topics.
Potential for submissions would be:
Symptomatic carotid artery management
Hyperperfusion syndrome
Carotid reocclusion in acute setting
Antiplatelet therapy in acute ischemic stroke due to tandem lesion
Carotid restenosis
Carotid artery disease prevention
Keywords: Ischemic stroke, stent, carotid artery, antiplatelet therapy, tandem lesion
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
