About this Research Topic

Background

Epilepsy is characterized by disruption of the excitatory and inhibitory balance in the central nervous system. In addition to neurotransmitters, this balance is provided by ionic transitions in the membrane. Therefore, the changes in transitions in both neurotransmitters and ions come to the fore in understanding epileptic seizures. Three main changes in ion channels that control ion passage determine the occurrence of seizures: mutations in the gene encoding the channel, functional changes, and change in channel expression. This Research Topic covers the targeting of changes in sodium, potassium, calcium, and all other ion channels in understanding the role of epilepsy and in the therapeutic process.

Our primary goal is to bring therapeutic research into remodeling the function of ion channels to this issue. Our next goal is to collect research and review articles showing that the functions of ion channels change, especially in post-ictal processes. The fact that ion channels change expression as well as function in the type of acquired epilepsy highlights the research of expression ion channels and associated receptors as a new target.

In conclusion, therapeutic approaches to ion channels, whose functions have been shown to change after seizures, and clinical/experimental studies targeting and investigating new ion channels will be evaluated in terms of ictogenesis and epileptogenesis.

The types of articles we are interested in are divided into four: brief research report, original research, case reports and review articles.

Expected research areas include but are not limited to:

- Ion channel studies in epilepsy types created with experimental models
- Receptor studies in the experimental model
- Ion channel researches on clinical data
- Electrophysiology of ion channels
- Cell culture research
- Review articles from experts in the field

Keywords: Ion-channel studies of epilepsy, Epilepsy models, K+ channels, Na+ channel, Ca2+ channel, electrophysiology

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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