Movement Disorders in Neurometabolic Conditions

Movement disorders form an integral part of several neurometabolic diseases. Neurometabolic disorders may either be acquired or inherited. In both these conditions, movement disorders occur frequently. Movement disorders may be an initial or presenting feature or may emerge during the course of the disease or its treatment. In inherited disorders, which usually emerge in the pediatric age group, the movement disorders phenomenology is usually complex and associated with the involvement of other neurological and non-neurological systems. The presence of movement disorders worsens quality of life, an impact which is over and above that caused by the neurometabolic disorder itself. At all points, it is crucial for the clinician to recognize those disorders which are considered to be ‘reversible’ or eminently treatable.

In this Research Topic, we aim to investigate neurometabolic disorders in which movement disorders form a crucial part of the clinical symptomatology, how they affect the patient or the caregiver, and newer advances in treatment, ranging from dietary manipulation to enzyme replacement therapies. This includes a focus on ‘reversible’ disorders. As these disorders are rare, researchers are encouraged to provide overviews of recent advances in the pathophysiology and treatment of movement disorders as they relate to neurometabolic disorders. We also welcome research on the expansions in clinical phenomenology and the emerging genetic landscapes in neurometabolic disorders in relationship to movement disorders.

This Research Topic specifically welcomes contributions in, but not limited to, the following fields:
• Genetic links in movement disorders linked to neurometabolic diseases
• Dietary manipulations in the management of movement disorders in neurometabolic diseases
• Managing movement disorders in neurometabolic conditions
• Reversible movement disorders in neurometabolic conditions
• Course and outcomes in movement disorders in neurometabolic conditions
• Movement Disorders registries in neurometabolic conditions
• Neurometabolic disorders presenting with movement disorders in adults

We welcome original research as well as:
• Learning case reports or case series, illustrating how movement disorders may serve to uncover an underlying neurometabolic disorder
• Systematic/ Mini Reviews/ Reviews
• Perspectives: Approach to movement disorders linked to neurometabolic conditions
• Methodology: Description of registries or clinical trial protocols