Primary liver cancer mainly includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), which is the sixth most diagnosed cancer and the third leading cause of cancer death worldwide. Previous studies have highlighted the contribution of the tumor microenvironment in the development and progression of primary liver cancer. The tumor microenvironment is a complex mixture composed of heterogeneous and interactive populations of cancer cells and distinct recruited stromal cell types. The interaction between the tumor microenvironment and cancer cells enhanced the malignant properties of cancer including proliferation, angiogenesis, metastasis, and therapy resistance. In addition, the tumor microenvironment also leads to abnormal angiogenesis and facilitates immunosuppression. Both HCC and ICC are usually resistant to targeted therapy and immunotherapy and urgently needed new therapy strategies. Targeting tumor microenvironment components to abrogate their tumor-supporting function has been an attractive potential therapeutic strategy for primary liver cancer. Further works to investigate the tumor microenvironment of primary liver cancer may favor the development of therapies for primary liver cancer.
In the past few years, the development of high throughput single-cell sequencing and other research techniques have dramatically improved the understanding of tumor microenvironments. However, much about the tumor microenvironment in primary liver cancer progression remains unknown. This Research Topic will focus on the emerging findings about the role and mechanism of tumor microenvironment in primary liver cancer development, metastasis, and therapy resistance. We welcome submissions of Original Research and Review focusing on but not limited to:
• Tumor microenvironment-related signaling pathway in primary liver cancer
• Crosstalk between tumor microenvironment and cancer cells
• Role of tumor microenvironment in liver cancer development and metastasis
• Tumor microenvironment and therapy resistance of primary liver cancer
• Potential primary liver cancer therapeutic targets via modulating the tumor microenvironment
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Primary liver cancer mainly includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), which is the sixth most diagnosed cancer and the third leading cause of cancer death worldwide. Previous studies have highlighted the contribution of the tumor microenvironment in the development and progression of primary liver cancer. The tumor microenvironment is a complex mixture composed of heterogeneous and interactive populations of cancer cells and distinct recruited stromal cell types. The interaction between the tumor microenvironment and cancer cells enhanced the malignant properties of cancer including proliferation, angiogenesis, metastasis, and therapy resistance. In addition, the tumor microenvironment also leads to abnormal angiogenesis and facilitates immunosuppression. Both HCC and ICC are usually resistant to targeted therapy and immunotherapy and urgently needed new therapy strategies. Targeting tumor microenvironment components to abrogate their tumor-supporting function has been an attractive potential therapeutic strategy for primary liver cancer. Further works to investigate the tumor microenvironment of primary liver cancer may favor the development of therapies for primary liver cancer.
In the past few years, the development of high throughput single-cell sequencing and other research techniques have dramatically improved the understanding of tumor microenvironments. However, much about the tumor microenvironment in primary liver cancer progression remains unknown. This Research Topic will focus on the emerging findings about the role and mechanism of tumor microenvironment in primary liver cancer development, metastasis, and therapy resistance. We welcome submissions of Original Research and Review focusing on but not limited to:
• Tumor microenvironment-related signaling pathway in primary liver cancer
• Crosstalk between tumor microenvironment and cancer cells
• Role of tumor microenvironment in liver cancer development and metastasis
• Tumor microenvironment and therapy resistance of primary liver cancer
• Potential primary liver cancer therapeutic targets via modulating the tumor microenvironment
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.