About this Research Topic
Notwithstanding the remarkable clinical and surgical advancements that have recently enhanced the therapeutical protocols for the treatment of patients with gliomas, a critical, evidence-based collection of up-to-date evidence is still foreseen. The novel classification of glioma based on the tumor molecular profile and its histological architecture and behavior has paved the way for a personalized approach to its treatment. Targeted biological agents, including molecular therapy, immunotherapy, and engineered host-derived cells represent a valuable adjunct to the conventional surgical micro resection. Moreover, the growing application of preoperative mapping techniques (transcranial magnetic stimulation, functional magnetic resonance imaging, and magnetoencephalography) as well as machine learning algorithms for predicting molecular traits and prognosis all convey exciting future directions showing promising results. The purpose of this Research Topic is thus to gather the most recent advancements in the pharmacological and surgical management of glioma.
The aim of this Research Topic is to collect recent evidence and novel experiences regarding tumor-specific molecular profiling and clinical management of gliomas with the contribution of experts in the field of neurosurgery and neuro-oncology. For instance, as recent progress demonstrates, a patient-oriented surgical and clinical approach represents the future of this field, granting a more specific assessment of the prognosis and therapeutical effectiveness let alone the containment of surgical complications.
Original articles and reviews investigating the molecular subtyping of gliomas as well as surgical and pharmacological advancements in the management of such malignancy are welcomed. A collection of innovative and pioneering data on multimodal management based on previously underestimated biological markers will offer the reader a complete narrative of the state of the art in the treatment of gliomas.
Keywords: Glioma - Targeted therapy - Molecular subtyping - Brain tumor - Chemotherapy - Immunotherapy - Preoperative mapping - Machine Learning
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