About this Research Topic
There are number of promising current approaches for obesity management, such as lifestyle modification, pharmacotherapy, and bariatric surgery. Also, the management of obesity has been improved to include natural compounds including probiotics, prebiotics, and synbiotics; synthetic drugs such as liraglutide, dietary interventions such as keto-diet; and intermittent fasting. However, a major concern that remains observed is the limited weight loss in the majority of the patients, particularly in children. Thus, the development and management of obesity still requires attention to overcome the issue and manage the downstream disease risk factors.
Another constant challenge is the emerging and progressive era of hepatic insulin resistance and related obesity. Research has detailed the mechanisms involved in this such as Serine/Threonine phosphorylation of IRS, inflammasome NLRP3, and ferroptosis. However, further exploration is required.
The study of obesity etiology has also progressed to illustrate the maternal role and genetic role in developing obesity in children. Current research has identified the effect of maternal obesity on fetal brain development.
The aim of this Research Topic is to gather original research manuscripts, meta-analyses, and review articles looking at hepatic insulin resistance, obesity and related disorders, e.g. type 2 diabetes, metabolic syndrome, neurodegenerative disorders, non-alcoholic fatty liver disease, hepatocellular carcinoma, and others. The research highlighting the effect of natural compounds, dietary intervention and synthetic drugs will be interesting. Moreover, highlighting molecular mechanisms that deal with positive/negative Serine/Threonine phosphorylation of IRS, inflammasome, and oxidative stress will also be considered. The above-mentioned potential topics are suggestions; other relevant topics will also be considered.
Keywords: Obesity, inflammation drugs, Natural compounds, Hepatic insulin resistance, dietary intervention
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