About this Research Topic
The bone system is a crucial part of the human body. Bone Metabolism Diseases including osteoporosis, osteoarthritis, and osteoarthritis have become more and more prevalent and rampant throughout the world. The primary bone tumor and bone metastasis of tumor cells have gradually become a major threat to human health worldwide too. However, there are no effective means for diagnosing and treating bone metabolism and bone-related tumor diseases in modern medicine. To overcome this problem, Medicinal foods, Natural products, and medicinal plants and preparations derived from them are to be the focus of considerable research interest. Single metabolites derived from medicinal plants and foods are important. They have become an essential part of complementary and alternative medicine in recent years. It is well known, that their secondary metabolites are important for biological activities and pharmacological effects, such as the promotion of osteogenic and antitumor effects. Unfortunately, the pathogenesis of bone metabolism and bone-related tumor diseases have not been fully elucidated, making its pharmacological treatment difficult. Therefore, the study of disease pathogenesis and treatment mechanism is so much important.
There is not a single system of ‘natural medicine’ but we find a diverse range of therapies using herbal medicines and the herbal products and isolated metabolites derived from then. So, it need to be much more precise and specific. Some compounds isolated from natural medicines have been reported as regulators of bone homeostasis in a multitarget manner. Cinobufagin, melittin, and baicalein exert antitumor activity and induce tumor cell apoptosis in osteosarcoma. Therefore, natural drugs require consideration for bone metabolism and bone-related tumor disease therapy.
The purpose of this research topic is to provide a platform for researchers who work on orthopedics, cancer, and ethnopharmacology to investigate the pathological mechanism of bone metabolism and bone-related tumor diseases and clarify the pharmacological mechanism of natural products, medicinal foods, and complementary and alternative medicine in the treatment of bone diseases. By elucidating the potential roles and regulatory mechanisms of the complex relationship between medicinal and food plants and bone diseases, a new understanding of how orthopedic diseases can be treated will result from this research topic. First, the aim is to examine the potential activity of natural products and identify the pathological effect on bone metabolism and bone-related tumor diseases. A secondary goal is to evaluate the pharmacodynamic constituents of natural medicines and knowledge about the protein targets of natural products. The final goal is to explore more effective treatment measures for orthopedic disease based on research results of candidate drugs.
This Research Topic aims to gather Original Research, Review, Mini-Review, Focused Review, Protocol, Method, Perspective, and Opinion articles concerning the following subtopics, including but not limited to:
• Evaluation of the pharmacological activity of natural products and medicinal plants including foods against bone metabolism and bone-related tumor diseases in vivo and in vitro.
• Analysis and extraction of medicinally active metabolites and the identification of inorganic compounds relevant for target diseases
• Clinical research of traditional herbs’ secondary metabolites with pharmacological activity against bone metabolism and bone-related tumor diseases.
• Bioinformatical analysis of the underlying mechanisms related to herbal Medicines and products derived from them may be considered. The can include but are not limited to network analysis. These must be conducted in combination with a detailed experimental pharmacological assessment. In silico studies without an experimental pharmacological approach are outside of the journal's scope.
• Identifying underlying mechanisms and finding suitable therapeutic agents of natural origin against bone metabolism and bone-related tumor diseases.
In all studies, the composition of the material investigated must be described in detail. For details see the ConPhyMP statement: Front. Pharmacol. 13:953205. doi: 10.3389/fphar.2022.953205’ WITH ‘All studies must comply with our guidelines - the four pillars of best practice in ethnopharmacology (see www.frontiersin.org/files/pdf/4_pillars_FULL_TEXT.pdf), and the composition of the material investigated must be described in detail. For details see the ConPhyMP statement: Front. Pharmacol. 13:953205. doi: 10.3389/fphar.2022.953205
There is not a single system of ‘natural medicine’ but we find a diverse range of therapies using herbal medicines and the herbal products and isolated metabolites derived from then. So, it need to be much more precise and specific. Some compounds isolated from natural medicines have been reported as regulators of bone homeostasis in a multitarget manner. Cinobufagin, melittin, and baicalein exert antitumor activity and induce tumor cell apoptosis in osteosarcoma. Therefore, natural drugs require consideration for bone metabolism and bone-related tumor disease therapy.
The purpose of this research topic is to provide a platform for researchers who work on orthopedics, cancer, and ethnopharmacology to investigate the pathological mechanism of bone metabolism and bone-related tumor diseases and clarify the pharmacological mechanism of natural products, medicinal foods, and complementary and alternative medicine in the treatment of bone diseases. By elucidating the potential roles and regulatory mechanisms of the complex relationship between medicinal and food plants and bone diseases, a new understanding of how orthopedic diseases can be treated will result from this research topic. First, the aim is to examine the potential activity of natural products and identify the pathological effect on bone metabolism and bone-related tumor diseases. A secondary goal is to evaluate the pharmacodynamic constituents of natural medicines and knowledge about the protein targets of natural products. The final goal is to explore more effective treatment measures for orthopedic disease based on research results of candidate drugs.
This Research Topic aims to gather Original Research, Review, Mini-Review, Focused Review, Protocol, Method, Perspective, and Opinion articles concerning the following subtopics, including but not limited to:
• Evaluation of the pharmacological activity of natural products and medicinal plants including foods against bone metabolism and bone-related tumor diseases in vivo and in vitro.
• Analysis and extraction of medicinally active metabolites and the identification of inorganic compounds relevant for target diseases
• Clinical research of traditional herbs’ secondary metabolites with pharmacological activity against bone metabolism and bone-related tumor diseases.
• Bioinformatical analysis of the underlying mechanisms related to herbal Medicines and products derived from them may be considered. The can include but are not limited to network analysis. These must be conducted in combination with a detailed experimental pharmacological assessment. In silico studies without an experimental pharmacological approach are outside of the journal's scope.
• Identifying underlying mechanisms and finding suitable therapeutic agents of natural origin against bone metabolism and bone-related tumor diseases.
In all studies, the composition of the material investigated must be described in detail. For details see the ConPhyMP statement: Front. Pharmacol. 13:953205. doi: 10.3389/fphar.2022.953205’ WITH ‘All studies must comply with our guidelines - the four pillars of best practice in ethnopharmacology (see www.frontiersin.org/files/pdf/4_pillars_FULL_TEXT.pdf), and the composition of the material investigated must be described in detail. For details see the ConPhyMP statement: Front. Pharmacol. 13:953205. doi: 10.3389/fphar.2022.953205
Keywords: Natural products, Medicinal foods, Complementary and Alternative Medicine, Bone Metabolism Diseases, Bone-related Tumor Diseases
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
