About this Research Topic
Autoimmune diseases are characterized by immune dysregulation, leading to immune-mediated damage of healthy tissues and cells. Despite increasing research, the exact cause of individual autoimmune disorders is not yet entirely understood. Pediatric autoimmune diseases, in particular, are often less extensively studied and present their own challenges to physicians in terms of diagnosis, as well as their treatment, often requiring a multidisciplinary approach. Understanding how autoimmune responses initiate and progress will allow us to develop novel therapeutics and improve disease management strategies.
Inborn errors of immunity (IEI) are genetic disorders that have recently been linked to a series of early-onset autoimmune disorders. An example is the LRBA deficiency which may manifest as a series of autoimmune diseases, including inflammatory bowel disease, endocrinopathies, autoimmune hemolytic anemia, thrombocytopenia, arthritis, and SLE. The IEI may also manifest as increased susceptibility to infections, autoinflammatory, allergic, and/or malignant diseases, however, there are few IEI in which an autoimmune manifestation has never been observed.
The goal of this Research Topic is to highlight and discuss research focusing on the pathogenesis of early-onset autoimmune diseases with the aim of increasing our knowledge on early-age symptoms. A better understanding of IEI and the genetic pathways between diseases will also help create new avenues for improving diagnoses and current treatment strategies. We welcome the submission of original research and review articles that cover, but are not limited to, the following sub-topics:
• The role of early-onset autoimmune diseases in unveiling new genes and pathways related to IEI
• The genetics of early-onset Type I Diabetes
• The role of NETs in the prototype of autoimmune disease – Systemic Lupus Erythematosus
• The role of the next-generation sequencing (NGS) target panel in the early diagnosis of IEI
• The role of regulatory cells and/or NK cells in the pathogenesis of autoimmune diseases.
• The role of immunothrombosis in childhood diseases
• The role of the inflammasome, autoantibodies, RAS family mutations, DNA repair diseases, and vitamin D in childhood autoimmune diseases
• The role of the passively transferred maternal autoantibodies in infant diseases
Inborn errors of immunity (IEI) are genetic disorders that have recently been linked to a series of early-onset autoimmune disorders. An example is the LRBA deficiency which may manifest as a series of autoimmune diseases, including inflammatory bowel disease, endocrinopathies, autoimmune hemolytic anemia, thrombocytopenia, arthritis, and SLE. The IEI may also manifest as increased susceptibility to infections, autoinflammatory, allergic, and/or malignant diseases, however, there are few IEI in which an autoimmune manifestation has never been observed.
The goal of this Research Topic is to highlight and discuss research focusing on the pathogenesis of early-onset autoimmune diseases with the aim of increasing our knowledge on early-age symptoms. A better understanding of IEI and the genetic pathways between diseases will also help create new avenues for improving diagnoses and current treatment strategies. We welcome the submission of original research and review articles that cover, but are not limited to, the following sub-topics:
• The role of early-onset autoimmune diseases in unveiling new genes and pathways related to IEI
• The genetics of early-onset Type I Diabetes
• The role of NETs in the prototype of autoimmune disease – Systemic Lupus Erythematosus
• The role of the next-generation sequencing (NGS) target panel in the early diagnosis of IEI
• The role of regulatory cells and/or NK cells in the pathogenesis of autoimmune diseases.
• The role of immunothrombosis in childhood diseases
• The role of the inflammasome, autoantibodies, RAS family mutations, DNA repair diseases, and vitamin D in childhood autoimmune diseases
• The role of the passively transferred maternal autoantibodies in infant diseases
Keywords: autoimmune diseases, childhood, early-onset, inborn errors of immunity (IEI), next-generation sequencing (NGS)
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
