About this Research Topic
The human microbiome, and particularly the gut microbiome, has emerged over the past 20 years as a key player in a variety of physiological and pathological processes. Several studies have revealed the important role of our microbial counterpart in modulating the host immune system and different metabolic pathways. Imbalance of microbiota profile, called dysbiosis, in the gut and in other body part during early life is associated with the development of various pediatric diseases, including allergy and atopy.
While the evidence on the relationship between microbiome and allergy/atopy has been expanded in the last few years, many questions remain unsolved. In particular, little is known about the factors that could induce a dysbiotic state predisposing to allergic disease, such as mode of delivery, antibiotic use during the early stage of microbiome development and diet. Moreover, while recent advancements in next-generation sequencing methods and metabolic studies have greatly improved our understanding of the architecture of the human microbiome, untangling some key biological interplays, there is no unified perspective on the characteristics on the mechanistic link between dysbiosis and the onset of allergic diseases. Lastly, the relationship between the microbiota at different body sites (gut, airways, skin, oral…) and different clinical entities should clearly be a focus of future research.
Suitable themes for manuscripts are:
• Gut microbiota and atopic disease in children
• The relationship between microbiome in different body sites and allergic diseases in children
• Metagenomics, metatranscriptomics, metabolomics and culturomics in the study of the relationship
• between allergy and the microbiome
• Asthma and airway microbiome
• Targeting the gut microbiome to prevent or treat allergic diseases
• Factors influencing microbiome development at early ages and the risk of developing atopic disease
• Atopic dermatitis and skin microbiome
• The role of nutrition in the pathogenesis of allergy
• Effect of anti-asthma drugs on microbiome
All article types accepted by Frontiers in Allergy are welcome.
While the evidence on the relationship between microbiome and allergy/atopy has been expanded in the last few years, many questions remain unsolved. In particular, little is known about the factors that could induce a dysbiotic state predisposing to allergic disease, such as mode of delivery, antibiotic use during the early stage of microbiome development and diet. Moreover, while recent advancements in next-generation sequencing methods and metabolic studies have greatly improved our understanding of the architecture of the human microbiome, untangling some key biological interplays, there is no unified perspective on the characteristics on the mechanistic link between dysbiosis and the onset of allergic diseases. Lastly, the relationship between the microbiota at different body sites (gut, airways, skin, oral…) and different clinical entities should clearly be a focus of future research.
Suitable themes for manuscripts are:
• Gut microbiota and atopic disease in children
• The relationship between microbiome in different body sites and allergic diseases in children
• Metagenomics, metatranscriptomics, metabolomics and culturomics in the study of the relationship
• between allergy and the microbiome
• Asthma and airway microbiome
• Targeting the gut microbiome to prevent or treat allergic diseases
• Factors influencing microbiome development at early ages and the risk of developing atopic disease
• Atopic dermatitis and skin microbiome
• The role of nutrition in the pathogenesis of allergy
• Effect of anti-asthma drugs on microbiome
All article types accepted by Frontiers in Allergy are welcome.
Keywords: Gut microbiome; pediatrics; allergy; atopic disease; short chain fatty acids; immune system; metagenomics; airway microbiome; skin microbiome.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
