There is a wide spectrum in thyroid dysfunction, the patient with advanced disease and symptoms described classically is rare in daily clinical practice. However, it is currently common to find patients with mild to moderate thyroid dysfunction. Most of these are identified in routine examinations or in evaluations made for nonspecific symptoms. This clinical scenario occurs with increasing frequency due to the increase in screening programs. Subclinical Thyroid Dysfunction is defined by a low or high serum thyroid-stimulating hormone (TSH) level, with normal free thyroxine (T4) and total or free triiodothyronine (T3) levels.
Subclinical thyroid dysfunction has been described in young people, adults and the elderly. Overt thyroid dysfunction has sufficient pathophysiological mechanisms to establish a relationship with the development of various pathologies such as obesity, depression, cardiovascular disease, and dyslipidemia. However, controversy remains; the association of subclinical thyroid dysfunction with various outcomes related to these pathologies as well as the benefit of receiving universal treatment. This is coupled with the fact that the risks and benefits of the treatment have not yet been fully clarified.
This Research Topic welcomes original research articles, clinical trials, reviews, and commentaries related to diagnosis, treatment, and physiopathology of subclinical thyroid dysfunction and its possible relation with other diseases like cardiovascular disease, hypertension, diabetes, depression, or other diseases possibly associated with thyroid dysfunction.
This collection is the second volume of
Subclinical Thyroid Disease: Present Knowledge and Future DirectionThere is a wide spectrum in thyroid dysfunction, the patient with advanced disease and symptoms described classically is rare in daily clinical practice. However, it is currently common to find patients with mild to moderate thyroid dysfunction. Most of these are identified in routine examinations or in evaluations made for nonspecific symptoms. This clinical scenario occurs with increasing frequency due to the increase in screening programs. Subclinical Thyroid Dysfunction is defined by a low or high serum thyroid-stimulating hormone (TSH) level, with normal free thyroxine (T4) and total or free triiodothyronine (T3) levels.
Subclinical thyroid dysfunction has been described in young people, adults and the elderly. Overt thyroid dysfunction has sufficient pathophysiological mechanisms to establish a relationship with the development of various pathologies such as obesity, depression, cardiovascular disease, and dyslipidemia. However, controversy remains; the association of subclinical thyroid dysfunction with various outcomes related to these pathologies as well as the benefit of receiving universal treatment. This is coupled with the fact that the risks and benefits of the treatment have not yet been fully clarified.
This Research Topic welcomes original research articles, clinical trials, reviews, and commentaries related to diagnosis, treatment, and physiopathology of subclinical thyroid dysfunction and its possible relation with other diseases like cardiovascular disease, hypertension, diabetes, depression, or other diseases possibly associated with thyroid dysfunction.
This collection is the second volume of
Subclinical Thyroid Disease: Present Knowledge and Future Direction