About this Research Topic
The findings mentioned above provide new therapeutic options for the control of infectious diseases and raise the question of whether NK cell-responses may be induced by vaccination and whether NK cells may be manipulated to boost their activity against viruses. Emerging data have shown that adaptive NK cells are involved in antiviral responses, including SARS-CoV-2, HIV-1, HBV, HCV. However, the mechanisms underlying the role of these cells in viral infections are largely undefined and require further investigation. The goal of this topic is to gather information on the role of innate immunity, as well as adaptive NK and trained immunity in the context of viral infections and vaccine responses.
The aim of this Research Topic is to evaluate the role of NK and adaptive NK cells in viral infections, with particular emphasis on SARS-CoV-2.
We welcome the submission of all article types, original research, reviews, perspective, brief research reports on the topics of interest, which include but are not limited to:
• Adaptive NK cells in SARS-CoV-2 infection
• Strategies to increase NK cell responses against viral infections
• Modulation of NK cell activity by viral peptides
• Trained immunity in viral infections
• Cytokine induced memory like NK cells in viral infections
• Mechanisms of viral immune evasion
• HLA and KIR in viral infections
• NK cells and vaccines
Keywords: Adaptive Natural Killer cells, Innate immunity, Trained immunity, Vaccine, SARS COV-2.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.