Viruses and Immune response in Pediatric Infection

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About this Research Topic

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Background

The development of many infectious diseases in children is related to viral infection and the immune response. These diseases may be initiated by viral infection, followed by a series of changes in the physiological function or/and structure of the child’s body. There are great differences between children and adults in terms of virus susceptibility and immune response. For example, compared to adults, children’s immune system is in the process of development and may mature gradually with the age. The lack of mature immunity makes newborns and infants more susceptible to infection that later tends to spread in their bodies, leading to a series of child-specific diseases. Also, as children's immunity matures gradually, the mechanism and extent of organ damage by the immune system may change and cause different clinical outcomes. Because of these characteristics of this category of diseases, pediatricians and relevant researchers need to reveal the pathogenesis and look for potential therapeutic targets.
This research topic focuses on the characteristics of the immune system in viral infection-related diseases in children, aiming to elucidate the pathology, physiology and changes of novel signaling pathways in such diseases. Through establishing various novel methods, expanding new concepts and exploring new molecular mechanisms, we hope to deeply understand the pathogenesis of virus-related infectious diseases in children and clarify the difference in immune system between adults and children in the process of viral infection. Finally, we aim to look for potential immunotherapeutic targets and apply novel therapeutic methods that may be applied in clinical practice in the future.
The purpose of this topic is to broaden the horizon and deepen the understanding of viral immune-related infectious disorders in children. We welcome clinical articles and basic research articles. Submissions including original research, reviews, and mini reviews which focus on, but are not limited to the following topics are highly encouraged.
1. The relationship between the “window phase” of virus infection in children and the maturation process of children's immune system and the related molecular mechanism
2. Roles of perinatal virus infection in neonatal digestive disorders and the pathogenesis
3. Relationship between innate/acquired immune response and prognosis of viral infection-related diseases in children
4. Molecular mechanism of virus infection related non-coding RNA in children's immune response
5. Microbiome study in the pathogenesis of viral infection-related diseases in children
6. Omics research on immune system changes in diseases induced by virus infection in children

Keywords: virus, infection, immune response, child, inflammation

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