Pathogenic Mechanisms, Injury Biomarkers, Prophylaxis and Treatment Strategy of Drug-Induced Nephrotoxicity

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Background

Currently, drug-induced nephrotoxicity (DIN) remains a global health challenge, and more than 12% of people worldwide are affected annually. Globally, the incidence of DIN has steadily increased for several decades; moreover, the kidney tissues of certain colonies (especially children, chronic patients, as well as old aged) are more easily assaulted by certain drugs. The irreversible pathological damage of DIN has led to a huge dilemma, which has caused great economic costs and physical pain for the patients and limited some medications’ multiple applications in the clinic. However, except for discontinued and/or reduced medication, we still have no other better response to protect it from damage because of a lack of deeper cognition of various DIN.



With the development of state-of-the-art technology, various examination and analytical instruments have been invented and employed in the medical sphere, for instance, frozen electron microscopy, real-time image, analysis of high-resolution magic angle rotating proton NMR spectroscopy, and so on, which all these facilitate the elaboration of pathogenic mechanisms and injury biomarkers of DIN. To further investigate the pathogenic or therapeutic targets of DIN, multi-omics technique strategies have been integrated with molecular biology (such as, x-RNA, gene, protein, and metabolite) and bioinformatics to determinate the potential injury biomarkers for early diagnosis and prediction, which all these provided a quantity of precondition for prophylaxis and treatment. Moreover, in recent experimental research, besides restriction/control the nephrotoxic drugs, certain phytomedicine interventions have also been promoted to prevent and/or treat renal injury. Based on the injury biomarkers and pathogenic mechanisms, many researchers are encouraged to develop early-precision diagnosis and prophylaxis measures and establish the corresponding treatment measures after kidney damage. However, these multimodal approaches and recognition theories of DIN still need to be further explored.



Hence, the current purpose of this Research Topic is to pronounce the deeper biomarker and mechanism recognition, as well as advanced technology integration for providing comprehensively previsions on early diagnosis, prophylaxis and curative treatment. The submissions of Original Research, Methods, Perspective, Review and Min-reviews, which are related to the Pathogenic mechanisms, injury biomarkers, as well as prophylaxis and treatment strategy of DIN are all encouraged and welcomed, but not limited to: the following topics:



-The pathology mechanism of DIN referred to the combined medications, including the western medications and herbal medicine, and the injury traits and cause which they caused the renal tissues and multi-angle deeper illustrations of DIN.

- The novel significance biomarkers from the gen, protein, metabolite and so on

- The innovation research techniques strategies, multi-model cross-application in mechanisms, biomarkers, prophylaxis and treatment strategy.

Keywords: drug-induced nephrotoxicity (DIN), Pathogenic mechanisms, injury biomarkers, kidney, phytomedicine

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