Regulation Roles of Ferroptosis-Related Genomics (mRNAs, lnc-RNAs, or micro-RNAs) In Human Malignant Cancers

About this Research Topic

Background

Cell death plays an essential role during the development and evolution of multicellular organisms. The progress of tumor treatments at different stages is always synchronized with human cognition for different modes of cell death. In the last decade, increasing studies have focussed on a new mode of cell death—ferroptosis. Ferroptosis was initially discovered as an iron-dependent and lipid-reactive oxygen species-accumulated mode of cellular death in 2012. It is distinct from previously known cell death modes including apoptosis, necrosis, and autophagy in both cell function and morphological characteristics. Its unique morphological characteristics include the increased density of mitochondrial membrane, shrinkage of cell mitochondria, and disappearance of mitochondrial cristae. In ferroptosis cells, cell membrane integrity is retained, the nucleus is normal in size, and chromatin is not concentrated; these characteristics are different from those of apoptosis and autophagy. Increasing studies have demonstrated that ferroptosis-related RNAs played a vital role in regulating malignant cell development, and targeted interference of ferroptosis-related RNAs was a promising strategy for future cancer treatment.

This research topic aimed to systematically demonstrate the regulation patterns designed by ferroptosis-related RNAs in all kinds of human malignancies and further explore promising values of ferroptosis-related RNAs in cancer development and medical treatment. This topic will further expand our understanding of ferroptosis-related RNAs in various human malignancies and also help to sort out the specific mechanisms in which ferroptosis-related RNAs tool part during cancer progressions. Moreover, this topic could take benefit in developing new drug therapies that interfere with the ferroptosis mechanism to overcome current cancer treatments.

Please note manuscripts consisting solely of bioinformatics or computational analysis of a single public genomic or transcriptomic database which are not accompanied by validation cohorts are out of the scope of this section and will not be accepted as part of this Research Topic. However, bioinformatics analysis with high quality or new analytical methods is also in the scope of this section.

We welcome the submission of Original Research, Reviews, Mini Reviews, Perspectives, and Opinions articles on the following themes:
• Novel studies concerning regulation roles of ferroptosis-related RNAs in human malignancies
• Detailed mechanism underlining ferroptosis-related RNAs in cancer developments and progressions
• Research and development of new small molecule drugs targeting ferroptosis-related RNAs to treat malignant cancers
• Specific biomarkers concerning ferroptosis-related RNAs in cancer developments
• Methods of utilizing ferroptosis-related RNAs to group cancers into distinct groups to guide clinical treatment or predict potential prognosis.

Keywords: Ferroptosis, RNAs, malignant cancer

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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