High altitude has been identified as an enormous stressor for both humans and animals. However, its effects on physiological processes in humans and animals have not been widely understood. Moreover, hypoxic stress at the cellular and molecular levels is the underlying mechanism of the response to high altitude. Living at or being exposed to high altitude without adequate acclimatization results in a variety of abnormal pathophysiological processes. Therefore, clinical and basic research on any aspect of physiology at high altitude is essential. In addition, the cardiovascular system has been shown to be one of the first response systems that is critical in compensating for hypoxic stress at high altitude. Numerous studies have demonstrated the response of the cardiovascular system to high altitude hypoxia. Normal, insufficient and excessive responses of the cardiovascular system have been reported and have been shown to be associated with high altitude disease. However, a large part of the physiological effects of high altitude has not been revealed clinically or mechanistically.
This Research Topic aims to provide a forum for researchers who discovered the manifestations and mechanisms of physiological and pathophysiological responses at high altitude and the response of the cardiovascular system to high altitude. We warmly welcome clinical and basic research on the physiological and pathophysiological responses to high altitude. In addition, diseases associated with high altitude, including acute mountain diseases and chronic mountain diseases, are also welcome topics. In addition, clinical and basic studies of the cardiovascular system and their role in high-altitude diseases are also accepted.
Specific sub topics include but are not limited to the following:
• Physiology and pathophysiology responses to high-altitude;
• Basic research of cardiovascular responses to high altitude or hypoxia;
• Systemic circulation at high altitude;
• Pulmonary circulation at high altitude;
• Cardiac functions response to high-altitude;
• Clinical studies on physiology and pathophysiology responses to high-altitude.
Keywords:
high-altitude hypoxia, pathophysiology, cardiovascular system, mountain sickness
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
High altitude has been identified as an enormous stressor for both humans and animals. However, its effects on physiological processes in humans and animals have not been widely understood. Moreover, hypoxic stress at the cellular and molecular levels is the underlying mechanism of the response to high altitude. Living at or being exposed to high altitude without adequate acclimatization results in a variety of abnormal pathophysiological processes. Therefore, clinical and basic research on any aspect of physiology at high altitude is essential. In addition, the cardiovascular system has been shown to be one of the first response systems that is critical in compensating for hypoxic stress at high altitude. Numerous studies have demonstrated the response of the cardiovascular system to high altitude hypoxia. Normal, insufficient and excessive responses of the cardiovascular system have been reported and have been shown to be associated with high altitude disease. However, a large part of the physiological effects of high altitude has not been revealed clinically or mechanistically.
This Research Topic aims to provide a forum for researchers who discovered the manifestations and mechanisms of physiological and pathophysiological responses at high altitude and the response of the cardiovascular system to high altitude. We warmly welcome clinical and basic research on the physiological and pathophysiological responses to high altitude. In addition, diseases associated with high altitude, including acute mountain diseases and chronic mountain diseases, are also welcome topics. In addition, clinical and basic studies of the cardiovascular system and their role in high-altitude diseases are also accepted.
Specific sub topics include but are not limited to the following:
• Physiology and pathophysiology responses to high-altitude;
• Basic research of cardiovascular responses to high altitude or hypoxia;
• Systemic circulation at high altitude;
• Pulmonary circulation at high altitude;
• Cardiac functions response to high-altitude;
• Clinical studies on physiology and pathophysiology responses to high-altitude.
Keywords:
high-altitude hypoxia, pathophysiology, cardiovascular system, mountain sickness
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.