About this Research Topic
Mitochondria play a pivotal role in bioenergetic and metabolic pathways, as well as cellular processes including oxidative stress, redox homeostasis, apoptosis, immunomodulation, and aging. Mitochondria can quickly adapt to meet the metabolic requirements of cells, effectively cross-talk with the nucleus to regulate stress responses, and maintain bioenergetic homeostasis under most conditions. Interestingly, a small family of recently found hormone-like mito-molecules revealed the new role of mitochondria in modulating body metabolism. Integrating local and systemic signals with proper mitochondrial function is critical for maintaining metabolic homeostasis. Mitochondrial defects and mitochondrial decline have been observed in metabolic disorders, age-related metabolic and degenerative diseases, aging, and cancer. Understanding how these pathways work together in the mitochondria in coordination with the nucleus to regulate dynamic bioenergetic and metabolic demands will potentially lead to therapeutic targets for age-related diseases and aging.
The aim of this Research Topic is to cover promising, recent, and novel research trends in understanding how bioenergetic, metabolic, and cellular pathways work together in the mitochondria in coordination with the nucleus to regulate dynamic bioenergetic and metabolic demands, as well as therapeutic targets for age-related diseases and aging.
We welcome the submissions of computational studies (supported by wet lab validation), comparative transcriptome analysis, proteomics, and studies on in vitro, cellular, and animal models. Areas to be covered in this Research Topic may include, but are not limited to:
• mitochondrial function
• mitochondrial biogenesis
• mitochondrial bioenergetics
• mitochondrial metabolic and cellular pathways
• reactive oxygen species generation and defense mechanisms
• interaction of mitochondria and other cellular organelles
• mito-peptides
• mitochondrial related disorders and diseases
• age-related diseases
• metabolic and mito-related aging
• drug targets and drug development for metabolic and mito-related aging
The aim of this Research Topic is to cover promising, recent, and novel research trends in understanding how bioenergetic, metabolic, and cellular pathways work together in the mitochondria in coordination with the nucleus to regulate dynamic bioenergetic and metabolic demands, as well as therapeutic targets for age-related diseases and aging.
We welcome the submissions of computational studies (supported by wet lab validation), comparative transcriptome analysis, proteomics, and studies on in vitro, cellular, and animal models. Areas to be covered in this Research Topic may include, but are not limited to:
• mitochondrial function
• mitochondrial biogenesis
• mitochondrial bioenergetics
• mitochondrial metabolic and cellular pathways
• reactive oxygen species generation and defense mechanisms
• interaction of mitochondria and other cellular organelles
• mito-peptides
• mitochondrial related disorders and diseases
• age-related diseases
• metabolic and mito-related aging
• drug targets and drug development for metabolic and mito-related aging
Keywords: mitochondrial bioenergetics, mitophagy, mitochondrial fusion/fission, ROS–mitochondrial oxidative defend systems, mitochondrial disorders and ageing
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
