Perioperative critical illness refers to a dysregulated inflammatory response and multi-organ dysfunction in critically ill patients in response to perioperative insults, such as ischemic-hypoxic injury, surgical/invasive procedures, sepsis, inflammation, and anesthetic intervention in the intensive care unit or operating theatre.
In contrast to the diagnosis and treatment of chronic diseases, the short-term perioperative medical costs of acute and severe diseases are very high, and they not only require a large number of medical resources but also create a great economic burden for families and society. This is a major challenge for global health care. And there are limited effective treatment options for perioperative critical illness, mainly owing to its unclear pathogenesis, lack of early-warning biomarkers, as well as the uncertain prognosis of invasive procedures and anesthetic interventions during the perioperative period. Therefore, it is of great importance to study the mechanisms and effective interventions for multi-organ dysfunction in critical diseases and to clarify the prognosis after the administration of different types of anesthetic drugs in the perioperative period.
With this Research Topic, we want to collect data on the occurrence and mechanisms of multi-organ dysfunction in critical diseases and search for potential intervention targets. We prefer exploration into the mechanisms of host immunity, and the interactions of different cell types (such as macrophages, endothelial cells, epithelial cells, and cardiomyocytes) and different organelles (such as mitochondria, endoplasmic reticulum, lysosome,) in a variety of critical illness models (such as hemorrhagic shock, sepsis, inflammatory infection, ischemia-reperfusion injury, severe surgical-invasive operation, and anesthetic intervention). Secondly, we also aim to investigate new monitoring/evaluation methods as well as early biomarkers for organ dysfunction in critically ill patients. Finally, the recent advances in therapeutic evaluation and new drug development for perioperative critical organ injury are also welcome in this research topic.
Authors are welcome to submit reviews, original research, and other article types on the following themes:
— Immune mechanisms of multi-organ dysfunction in critical disease
— Monitoring or evaluation measures for organ dysfunction in critical disease.
— Early biomarkers for organ dysfunction in critical disease.
— Effects of anesthetic drugs on organ functions in perioperative period.
Perioperative critical illness refers to a dysregulated inflammatory response and multi-organ dysfunction in critically ill patients in response to perioperative insults, such as ischemic-hypoxic injury, surgical/invasive procedures, sepsis, inflammation, and anesthetic intervention in the intensive care unit or operating theatre.
In contrast to the diagnosis and treatment of chronic diseases, the short-term perioperative medical costs of acute and severe diseases are very high, and they not only require a large number of medical resources but also create a great economic burden for families and society. This is a major challenge for global health care. And there are limited effective treatment options for perioperative critical illness, mainly owing to its unclear pathogenesis, lack of early-warning biomarkers, as well as the uncertain prognosis of invasive procedures and anesthetic interventions during the perioperative period. Therefore, it is of great importance to study the mechanisms and effective interventions for multi-organ dysfunction in critical diseases and to clarify the prognosis after the administration of different types of anesthetic drugs in the perioperative period.
With this Research Topic, we want to collect data on the occurrence and mechanisms of multi-organ dysfunction in critical diseases and search for potential intervention targets. We prefer exploration into the mechanisms of host immunity, and the interactions of different cell types (such as macrophages, endothelial cells, epithelial cells, and cardiomyocytes) and different organelles (such as mitochondria, endoplasmic reticulum, lysosome,) in a variety of critical illness models (such as hemorrhagic shock, sepsis, inflammatory infection, ischemia-reperfusion injury, severe surgical-invasive operation, and anesthetic intervention). Secondly, we also aim to investigate new monitoring/evaluation methods as well as early biomarkers for organ dysfunction in critically ill patients. Finally, the recent advances in therapeutic evaluation and new drug development for perioperative critical organ injury are also welcome in this research topic.
Authors are welcome to submit reviews, original research, and other article types on the following themes:
— Immune mechanisms of multi-organ dysfunction in critical disease
— Monitoring or evaluation measures for organ dysfunction in critical disease.
— Early biomarkers for organ dysfunction in critical disease.
— Effects of anesthetic drugs on organ functions in perioperative period.