About this Research Topic
Throughout the history of humanity, we have managed to observe the aggressiveness of certain viruses that have claimed the lives of millions of individuals. However, most of the viruses we coexist with go unnoticed by most of us. This phenomenon is explained mostly by the individual's immunogenetics, which is an essential part of evolution. Immunogenetics has provided a deep understanding of fundamental biological processes.
Advances in this field have helped to understand the main histocompatibility complex functions and how this could help in medical procedures. To date, polygenic studies assessing the combined gene effects show the importance of implementing a systemic approach to evaluate the immune system response to infections caused by pathogens such as viruses.
Given the importance of the current COVID-19 pandemic, it is important to generate a special topic that allows us to compile the most relevant original studies and review articles on this topic.
The goal of this topic is to gather scientific evidence that allows us to understand why the immune genome of each individual responds differently to SARS-CoV-2 infection. Additionally, this topic will allow the identification of gene variants that can be considered as biomarkers for predicting the outcome of COVID-19.
The scientific evidence published on this topic might contribute to the diagnostic approach and therapeutic intervention for patients at high risk of developing critical outcomes of COVID-19.
Scientific evidence and research articles are required to elucidate how clinical and genetic scenarios contribute to differentiating the outcome of patients infected by SARS CoV-2. Therefore, it is important to investigate the involvement of gene variants in molecular mechanisms related to:
1. SARS-CoV-2 infection
2. Myddosome Assembly
3. Antigen Processing
4. Antigen Presentation
5. Inflammasome Assembly
6. Cytokines
7. Immune Synapse
8. Pyroptosis
Advances in this field have helped to understand the main histocompatibility complex functions and how this could help in medical procedures. To date, polygenic studies assessing the combined gene effects show the importance of implementing a systemic approach to evaluate the immune system response to infections caused by pathogens such as viruses.
Given the importance of the current COVID-19 pandemic, it is important to generate a special topic that allows us to compile the most relevant original studies and review articles on this topic.
The goal of this topic is to gather scientific evidence that allows us to understand why the immune genome of each individual responds differently to SARS-CoV-2 infection. Additionally, this topic will allow the identification of gene variants that can be considered as biomarkers for predicting the outcome of COVID-19.
The scientific evidence published on this topic might contribute to the diagnostic approach and therapeutic intervention for patients at high risk of developing critical outcomes of COVID-19.
Scientific evidence and research articles are required to elucidate how clinical and genetic scenarios contribute to differentiating the outcome of patients infected by SARS CoV-2. Therefore, it is important to investigate the involvement of gene variants in molecular mechanisms related to:
1. SARS-CoV-2 infection
2. Myddosome Assembly
3. Antigen Processing
4. Antigen Presentation
5. Inflammasome Assembly
6. Cytokines
7. Immune Synapse
8. Pyroptosis
Keywords: Immunogenetics, SARS-CoV-2, Gene Variants, COVID-19, Immune System, Polymorphism
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
